A maximum entropy algorithm for holographic structure completion in macromolecular x-ray crystallography

We discuss the historical origin of the holographic concept in the field of crystallography and its relation to modern applications of similar ideas to the problem of structure completion in macromolecular x-ray crystallography. For structure completion, the identification of the diffracted amplitude from the known part of the structure with a reference wave enables the recovery of the unknown part of the electron density from the diffraction intensities. Ln this article, we show how this may be achieved by means of a maximum entropy algorithm.