Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown

被引：13
作者：
Breyer, Marie-Kathrin [1 ,2 ,8 ]
Breyer-Kohansal, Robab [1 ,2 ]
Hartl, Sylvia [1 ,2 ,3 ]
Kundi, Michael [4 ]
Weseslindtner, Lukas [5 ]
Stiasny, Karin [5 ]
Puchhammer-Stoeckl, Elisabeth [5 ]
Schrott, Andrea [2 ]
Foedinger, Manuela [3 ,6 ]
Binder, Michael [7 ]
Fiedler, Markus [2 ]
Wouters, Emiel F. M. [2 ]
Burghuber, Otto C. [2 ,3 ]
机构：
[1] Clin Penzing, Dept Resp & Crit Care Med, Vienna, Austria
[2] Ludwig Boltzmann Inst Lung Hlth, Vienna, Austria
[3] Sigmund Freud Univ, Fac Med, Vienna, Austria
[4] Med Univ Vienna, Ctr Publ Hlth, Vienna, Austria
[5] Med Univ Vienna, Ctr Virol, Vienna, Austria
[6] Clin Favoriten, Inst Lab Diagnost, Vienna, Austria
[7] Vienna Healthcare Grp, Vienna, Austria
[8] Ludwig Boltzmann Inst Lung Hlth, Austrian LEAD Study, Klink Penzing, Gebaude G,2 Stock,Sanatoriumstr 2, A-1140 Vienna, Austria
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
关键词：
D O I：
10.1038/s41598-021-89711-5
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We analyzed SARS-CoV-2 seroprevalence in a large, well-described representative Viennese cohort after an early governmental lockdown with respect to the occurrence of symptoms and household transmission. Participants of the LEAD Study, a population-based cohort study from Vienna, Austria, were invited along with their household members (April 20th to May20th 2020). Sera were analyzed using anti-SARS-CoV-2 immunoassay including a neutralization test as a confirmatory assay. A total of 12,419 individuals participated (5984 LEAD participants; 6435 household members), 163 (1.31%; 59 LEAD cohort members) of whom were SARS-CoV-2 antibody positive. The estimated number of COVID-19 cases projected from our findings by age and sex for Vienna was 21,504 (1.13%). Cumulative number of positively tested cases in Vienna until May 20th 2020 was 3020, hence 7.1 times (95% confidence interval 5.5-9.1) lower than projected. Relative risk (RR) of seropositivity by age was highest for children aged 6-9 years [RR compared to age group 20-49: 1.21 (CI 0.37-4.01)], lowest for >= 65 years [RR 0.47 (CI 0.21-1.03)]. Half of the positive individuals developed no or mild symptoms. In a multivariate analysis, taste and smell disturbances were most strongly related to SARS-CoV-2 positivity. Infection probability within households with one confirmed SARS-CoV-2-specific antibody-positive person was 31%. Although seroprevalence was very low (1.13%) for a central European capital city, due to an early governmental lockdown, SARS-CoV-2 infections were more prevalent than officially reported polymerase chain reaction-positive cases. Of note, seroprevalence was highest in young children. Half of SARS-CoV-2 antibody-positive subjects had no or only mild symptoms. Taste and smell disturbances were most prominent, possibly guiding clinicians in diagnosing SARS-CoV-2 infection.
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