Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

被引：90

作者：

Bastos, Andre M. ^{[1
,2
,5
,6
]}

Donoghue, Jacob A. ^{[1
,2
]}

Brincat, Scott L. ^{[1
,2
]}

Mahnke, Meredith ^{[1
,2
]}

Yanar, Jorge ^{[1
,2
]}

Correa, Josefina ^{[1
,2
]}

Waite, Ayan S. ^{[1
,2
]}

Lundqvist, Mikael ^{[1
,2
]}

Roy, Jefferson ^{[1
,2
]}

Brown, Emery N. ^{[1
,2
,3
,4
]}

Miller, Earl K. ^{[1
,2
]}

机构：

[1] MIT, Picower Inst Learning & Memory, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02115 USA

[4] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA

[6] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37240 USA

来源：

ELIFE | 2021年 / 10卷

关键词：

GENERAL-ANESTHESIA; ELECTRICAL-STIMULATION; CONSCIOUSNESS; EMERGENCE; CORTEX; REANIMATION; MECHANISMS; RHYTHM; EEG; NEUROSCIENCE;

D O I：

10.7554/eLife.60824

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The specific circuit mechanisms through which anesthetics induce unconsciousness have not been completely characterized. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with the anesthetic propofol. Unconsciousness was marked by slow frequency (similar to 1 Hz) oscillations in local field potentials, entrainment of local spiking to Up states alternating with Down states of little or no spiking activity, and decreased coherence in frequencies above 4 Hz. Thalamic stimulation 'awakened' anesthetized NHPs and reversed the electrophysiologic features of unconsciousness. Unconsciousness is linked to cortical and thalamic slow frequency synchrony coupled with decreased spiking, and loss of higher-frequency dynamics. This may disrupt cortical communication/integration.

引用

页数：28

共 75 条

[1] NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION [J].