Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

被引：39

作者：

Quintard, Adrien ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 23期

关键词：

ORGANOCATALYTIC CONJUGATE ADDITION; ALPHA; ALPHA-DISUBSTITUTED ALDEHYDES; MICHAEL ADDITION; AMINO-ACIDS; CHLORINATION; CONSTRUCTION; AMINATION; NITROOLEFINS; NITROALKENES; CATALYSIS;

D O I：

10.1039/c000326c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aminal-pyrrolidine catalysed addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.

引用

页码：4085 / 4087

页数：3

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