Distribution of VIP receptors in the human submandibular gland: an immunohistochemical study

被引：0

作者：

Kusakabe, T

Matsuda, H

Gono, Y

Kawakami, T

Kurihara, K

Tsukuda, M

Takenaka, T

机构：

[1] Yokohama City Univ, Sch Med, Dept Anat, Yokohama, Kanagawa 236, Japan

[2] Yokohama City Univ, Sch Med, Dept Otorhinolaryngol, Yokohama, Kanagawa 236, Japan

[3] Kitasato Univ, Sch Med, Dept Physiol, Sagamihara, Kanagawa 228, Japan

[4] Kitasato Univ, Sch Med, Dept Legal Med, Sagamihara, Kanagawa 228, Japan

[5] Yokohama City Univ, Sch Med, Dept Physiol, Yokohama, Kanagawa 236, Japan

来源：

HISTOLOGY AND HISTOPATHOLOGY | 1998年 / 13卷 / 02期

关键词：

submandibular gland; VIP; VIP receptor; immunohistochemistry; humans;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Distribution of vasoactive intestinal polypeptide (VIP)-immunoreactive nerve fibers and VIP-receptor (VIP-R)-immunoreactive sites in the human submandibular gland were examined by the peroxidase-antiperoxidase method using the specimens taken from patients that had not received radiotherapy. VIP-immunoreactive fibers were found around both serous and mucous acini, the duct system, and those around the mucous acini were more numerous than those around the serous acini. VIP-R immunoreactivity was restricted to the mucous acini and the intercalated duct segment. The serous acini, striated duct, and excretory ducts lacked VIP-R immunoreactivity. These findings suggest that the mucous acinar cells contain VIP-R, and that VIP-R-mediated VIP action is involved in regulating synthesis of viscous saliva and its release.

引用

页码：373 / 378

页数：6

共 19 条

[1] VASOACTIVE INTESTINAL PEPTIDE INTERACTS WITH ALPHA-ADRENERGIC-P-MEDIATED, CHOLINERGIC-P-MEDIATED, AND SUBSTANCE-P-MEDIATED RESPONSES IN RAT PAROTID AND SUBMANDIBULAR GLANDS
BOBYOCK, E
CHERNICK, WS
[J]. JOURNAL OF DENTAL RESEARCH, 1989, 68 (11) : 1489 - 1494
[2] DESCHODTLANCKMAN M, 1975, GASTROENTEROLOGY, V68, P318
[3] Neuropeptide Y in salivary glands of the rat: Origin, release and secretory effects
Ekstrom, J
Ekman, R
Luts, A
Sundler, F
Tobin, G
[J]. REGULATORY PEPTIDES, 1996, 61 (02) : 125 - 134
[4] SECRETION OF PROTEIN FROM SALIVARY-GLANDS IN THE FERRET IN RESPONSE TO VASOACTIVE INTESTINAL PEPTIDE
EKSTROM, J
TOBIN, G
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1989, 415 : 131 - 141
[5] BILATERAL IRRADIATION OF HEAD AND NECK INDUCES AN ENHANCED EXPRESSION OF SUBSTANCE-P IN THE PARASYMPATHETIC INNERVATION OF THE SUBMANDIBULAR-GLAND
FORSGREN, S
FRANZEN, L
FUNEGARD, U
GUSTAFSSON, H
HENRIKSSON, R
[J]. NEUROSCIENCE, 1992, 46 (01) : 233 - 240
[6] FRANZEN L, 1991, LAB INVEST, V64, P279
[7] NEUROPEPTIDES IN HUMAN SALIVARY (SUBMANDIBULAR AND PAROTID) GLANDS
HAUSERKRONBERGER, C
ALBEGGER, K
SARIA, A
HACKER, GW
[J]. ACTA OTO-LARYNGOLOGICA, 1992, 112 (02) : 343 - 348
[8] LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE-RECEPTOR-IMMUNOREACTIVITY IN HUMAN SALIVARY-GLANDS
HERBST, WM
KUMMER, W
HEYM, C
[J]. NEUROPEPTIDES, 1992, 22 (02) : 89 - 92
[9] FUNCTIONAL EXPRESSION AND TISSUE DISTRIBUTION OF A NOVEL RECEPTOR FOR VASOACTIVE INTESTINAL POLYPEPTIDE
ISHIHARA, T
SHIGEMOTO, R
MORI, K
TAKAHASHI, K
NAGATA, S
[J]. NEURON, 1992, 8 (04) : 811 - 819
[10] LOCALIZATION OF SUBSTANCE-P, CGRP, VIP, NEUROPEPTIDE-Y, AND SOMATOSTATIN IMMUNOREACTIVE NERVE-FIBERS IN THE CAROTID LABYRINTHS OF SOME AMPHIBIAN SPECIES
KUSAKABE, T
ANGLADE, P
TSUJI, S
[J]. HISTOCHEMISTRY, 1991, 96 (03) : 255 - 260

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