Skeletal Stem Cells in Space and Time

被引:46
作者
Kassem, Moustapha [1 ,2 ]
Bianco, Paolo [3 ]
机构
[1] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense C, Denmark
[2] Univ Copenhagen, Panum Inst, Danish Stem Cell Ctr DanStem, DK-2200 Copenhagen, Denmark
[3] Univ Roma La Sapienza, Dept Mol Med, I-00161 Rome, Italy
关键词
BONE;
D O I
10.1016/j.cell.2014.12.034
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The nature, biological characteristics, and contribution to organ physiology of skeletal stem cells are not completely determined. Chan et al. and Worthley et al. demonstrate that a stem cell for skeletal tissues, and a system of more restricted, downstream progenitors, can be identified in mice and demonstrate its role in skeletal tissue maintenance and regeneration.
引用
收藏
页码:17 / 19
页数:4
相关论文
共 10 条
[1]   New factors controlling the balance between osteoblastogenesis and adipogenesis [J].
Abdallah, Basem M. ;
Kassem, Moustapha .
BONE, 2012, 50 (02) :540-545
[2]   The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine [J].
Bianco, Paolo ;
Cao, Xu ;
Frenette, Paul S. ;
Mao, Jeremy J. ;
Robey, Pamela G. ;
Simmons, Paul J. ;
Wang, Cun-Yu .
NATURE MEDICINE, 2013, 19 (01) :35-42
[3]   Identification and Specification of the Mouse Skeletal Stem Cell [J].
Chan, Charles K. F. ;
Seo, Eun Young ;
Chen, James Y. ;
Lo, David ;
McArdle, Adrian ;
Sinha, Rahul ;
Tevlin, Ruth ;
Seita, Jun ;
Vincent-Tompkins, Justin ;
Wearda, Taylor ;
Lu, Wan-Jin ;
Senarath-Yapa, Kshemendra ;
Chung, Michael T. ;
Marecic, Owen ;
Tran, Misha ;
Yan, Kelley S. ;
Upton, Rosalynd ;
Walmsley, Graham G. ;
Lee, Andrew S. ;
Sahoo, Debashis ;
Kuo, Calvin J. ;
Weissman, Irving L. ;
Longaker, Michael T. .
CELL, 2015, 160 (1-2) :285-298
[4]  
Friedenstein AJ., 1988, CIBA F SYMP, P42, DOI 10.1002/9780470513637.ch4
[5]   Mesenchymal and haematopoietic stem cells form a unique bone marrow niche [J].
Mendez-Ferrer, Simon ;
Michurina, Tatyana V. ;
Ferraro, Francesca ;
Mazloom, Amin R. ;
MacArthur, Ben D. ;
Lira, Sergio A. ;
Scadden, David T. ;
Ma'ayan, Avi ;
Enikolopov, Grigori N. ;
Frenette, Paul S. .
NATURE, 2010, 466 (7308) :829-U59
[6]   Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development [J].
Mizoguchi, Toshihide ;
Pinho, Sandra ;
Ahmed, Jalal ;
Kunisaki, Yuya ;
Hanoun, Maher ;
Mendelson, Avital ;
Ono, Noriaki ;
Kronenberg, Henry M. ;
Frenette, Paul S. .
DEVELOPMENTAL CELL, 2014, 29 (03) :340-349
[7]   The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche [J].
Omatsu, Yoshiki ;
Sugiyama, Tatsuki ;
Kohara, Hiroshi ;
Kondoh, Gen ;
Fujii, Nobutaka ;
Kohno, Kenji ;
Nagasawa, Takashi .
IMMUNITY, 2010, 33 (03) :387-399
[8]   Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment [J].
Sacchetti, Benedetto ;
Funari, Alessia ;
Michienzi, Stefano ;
Di Cesare, Silvia ;
Piersanti, Stefania ;
Saggio, Isabella ;
Tagliafico, Enrico ;
Ferrari, Stefano ;
Robey, Pamela Gehron ;
Riminucci, Mara ;
Bianco, Paolo .
CELL, 2007, 131 (02) :324-336
[9]   Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential [J].
Worthley, Daniel L. ;
Churchill, Michael ;
Compton, Jocelyn T. ;
Tailor, Yagnesh ;
Rao, Meenakshi ;
Si, Yiling ;
Levin, Daniel ;
Schwartz, Matthew G. ;
Uygur, Aysu ;
Hayakawa, Yoku ;
Gross, Stefanie ;
Renz, Bernhard W. ;
Setlik, Wanda ;
Martinez, Ashley N. ;
Chen, Xiaowei ;
Nizami, Saqib ;
Lee, Heon Goo ;
Kang, H. Paco ;
Caldwell, Jon-Michael ;
Asfaha, Samuel ;
Westphalen, C. Benedikt ;
Graham, Trevor ;
Jin, Guangchun ;
Nagar, Karan ;
Wang, Hongshan ;
Kheirbek, Mazen A. ;
Kolhe, Alka ;
Carpenter, Jared ;
Glaire, Mark ;
Nair, Abhinav ;
Renders, Simon ;
Manieri, Nicholas ;
Muthupalani, Sureshkumar ;
Fox, James G. ;
Reichert, Maximilian ;
Giraud, Andrew S. ;
Schwabe, Robert F. ;
Pradere, Jean-Phillipe ;
Walton, Katherine ;
Prakash, Ajay ;
Gumucio, Deborah ;
Rustgi, Anil K. ;
Stappenbeck, Thaddeus S. ;
Friedman, Richard A. ;
Gershon, Michael D. ;
Sims, Peter ;
Grikscheit, Tracy ;
Lee, Francis Y. ;
Karsenty, Gerard ;
Mukherjee, Siddhartha .
CELL, 2015, 160 (1-2) :269-284
[10]   Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow [J].
Zhou, Bo O. ;
Yue, Rui ;
Murphy, Malea M. ;
Peyer, James G. ;
Morrison, Sean J. .
CELL STEM CELL, 2014, 15 (02) :154-168