Magnetic Nanoparticles in Targeted Drug Delivery: a Review

被引:156
|
作者
Kianfar, Ehsan [1 ,2 ]
机构
[1] Islamic Azad Univ, Dept Chem Engn, Arak Branch, Arak, Iran
[2] Islamic Azad Univ, Gachsaran Branch, Young Researchers & Elite Club, Gachsaran, Iran
关键词
Magnetic nanoparticles; Nanostructures; Drug delivery; Biomedical; Body; SELF-ASSEMBLED NANOPARTICLES; CELL-PENETRATING PEPTIDES; MODIFIED GLYCOL CHITOSAN; SOLID-PHASE EXTRACTION; ENDOPLASMIC-RETICULUM; SILICA NANOPARTICLES; CANCER-CELLS; ELECTRICAL-CONDUCTIVITY; INTRACELLULAR DELIVERY; DIELECTRIC-PROPERTIES;
D O I
10.1007/s10948-021-05932-9
中图分类号
O59 [应用物理学];
学科分类号
摘要
Magnetic nanoparticles are one of the most important and widely used types of nanomaterials, whose unique properties make them special compared to other nanostructures. These particles can be used in various fields. But their role in biomedicine, especially in the field of drug delivery, is significant because their inherent magnetism facilitates many tasks, including targeting, which is very important and necessary in drug delivery. In the present article, an attempt has been made to give general information about magnetic nanoparticles and the properties of particles in biomedical applications. In the following, special attention has been paid to the properties of these particles in drug delivery and their various applications have been studied. The importance of coating magnetic nanoparticles has also been mentioned as a basic requirement for medical applications. In the following, the method of drug loading in magnetic nanoparticles, the entry of particles into the body, targeting, and drug release are discussed, and finally, a brief discussion is presented regarding the pharmacokinetics of drugs and their toxicity in the body.
引用
收藏
页码:1709 / 1735
页数:27
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