Variation of sentinel lymphatic channels (SLCs) and sentinel lymph nodes (SLNs) assessed by contrast-enhanced ultrasound (CEUS) in breast cancer patients

被引：31

作者：

Wang, Ying ^{[1
]}

Zhou, Wenbin ^{[1
]}

Li, Cuiying ^{[2
]}

Gong, Haiyan ^{[2
]}

Li, Chunlian ^{[1
]}

Yang, Nianzhao ^{[3
]}

Zha, Xiaoming ^{[1
]}

Chen, Lin ^{[1
]}

Xia, Tiansong ^{[1
]}

Liu, Xiaoan ^{[1
]}

Wang, Minghai ^{[3
]}

Ding, Qiang ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Ultrasound, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[3] Wannan Med Coll, Affiliated Yijishan Hosp 1, Dept Gen Surg, Wuhu, Anhui, Peoples R China

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2017年 / 15卷

关键词：

Breast cancer; Contrast-enhanced ultrasound; Sentinel lymphatic channel; Sentinel lymph node; INTRADERMAL MICROBUBBLES; SWINE MODEL; BIOPSY; LYMPHOGRAPHY; ULTRASONOGRAPHY; IDENTIFICATION; DISSECTION;

D O I：

10.1186/s12957-017-1195-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The objective of this study was to assess the feasibility of detecting the variation of sentinel lymphatic channels (SLCs) and sentinel lymph nodes (SLNs) in breast cancer patients using contrast-enhanced ultrasound (CEUS). Methods: A total of 46 breast cancer patients were prospectively recruited in the study. All the participants received intradermal and peritumoral injection of microbubbles as contrast agent, and SLCs and SLNs were assessed preoperatively. Blue dye was injected subareolarly and peritumorally during the surgery. The SLNs detected by CEUS and blue dye were sent to the pathology laboratory for histopathological analysis. Results: At least one SLC and SLN were detected by CEUS in all 46 cases. Three types of SLCs were detected, including superficial sentinel lymphatic channels (SSLCs), penetrating sentinel lymphatic channels (PSLCs), and deep sentinel lymphatic channels (DSLCs). Five lymphatic drainage patterns (LDPs) were found, including SSLC, PSLC, SSLC + PSLC, SSLC + DSLC, and SSLC + PSLC + DSLC. Only SSLC was detected on CEUS in 24 cases; only PSLC was detected in 3 cases; both SSLC and PSLC were detected in 8 cases; both SSLC and DSLC were detected in 7 cases; SSLC, PSLC, and DSLC were all detected in the remaining 4 cases. An actual LDP was defined on the combination of CEUS and dissection of the specimen. The accuracy rate of CEUS was 43/46. Interestingly, a bifurcated SLC was found in 8 patients. In 3 patients, a discontinuous SLC and non-enhanced SLN were found by CEUS. Also, no dyed SLNs were detected during the surgery. The axillary lymph nodes turned out tumor involved histologically. Conclusion: CEUS is feasible to assess the variation of SLCs and SLNs preoperatively in breast cancer patients. SLNB is not suggested when a discontinuous SLC and non-enhanced SLN were detected by CEUS.

引用

页数：7

共 25 条

[1] Validation of a technique using microbubbles and contrast enhanced ultrasound (CEUS) to biopsy sentinel lymph nodes (SLN) in pre-operative breast cancer patients with a normal grey-scale axillary ultrasound [J].