Depression in people with type 2 diabetes: current perspectives

被引：91
作者：
Darwish, Lina [1 ,2 ,3 ,4 ]
Beroncal, Erika [1 ,2 ,3 ]
Sison, Ma Veronica [1 ,2 ,3 ]
Swardfager, Walter [1 ,2 ,3 ,4 ]
机构：
[1] Sunnybrook Res Inst, Hurvitz Brain Sci Program, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
[3] Univ Hlth Network, Cardiac Rehabil Program, Toronto Rehabil Inst, Toronto, ON, Canada
[4] Canadian Partnership Stroke Recovery, Toronto, ON, Canada
来源：
DIABETES METABOLIC SYNDROME AND OBESITY | 2018年 / 11卷
关键词：
type; 2; diabetes; depression; mood; complications; IMPAIRED GLUCOSE REGULATION; SERIOUS MENTAL-ILLNESS; ALL-CAUSE MORTALITY; WELL-BEING INDEX; GLYCEMIC CONTROL; COMORBID DEPRESSION; MENDELIAN RANDOMIZATION; PSYCHOMETRIC PROPERTIES; MEDICATION ADHERENCE; EUROPEAN DEPRESSION;
D O I：
10.2147/DMSO.S106797
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration. The latter considerations contribute to a "J-shaped" trajectory from the time of diagnosis. There remain significant challenges to screening for clinical risks associated with psychological symptoms in T2DM; poorer outcomes may be associated with major depressive episodes, isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like symptoms more specific to T2DM (eg, diabetes-related distress), apathy or fatigue. In this review, we discuss current perspectives on depression in the context of T2DM with implications for screening and management of these highly comorbid conditions.
引用
收藏
页码：333 / 343
页数：11
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