Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

被引：13

作者：

Angosto-Bazarra, Diego ^{[1
]}

Molina-Lopez, Cristina ^{[1
]}

Penin-Franch, Alejandro ^{[1
]}

Hurtado-Navarro, Laura ^{[1
]}

Pelegrin, Pablo ^{[1
]}

机构：

[1] Hosp Clin Univ Virgen de la Arrixaca, Inst Murciano Invest Biosanitaria IMIB Arrixaca, Linea Inflamac Mol, Murcia 30120, Spain

来源：

MOLECULES | 2021年 / 26卷 / 06期

基金：

欧洲研究理事会;

关键词：

inflammasomes; small molecules; techniques to assay inflammasome activation; auto-active inflammasomes; NLRP3; inhibitors; INDUCED CELL-DEATH; NLRP3; INFLAMMASOME; AUTOINFLAMMATORY DISEASE; AIM2; NLRC4; CAUSES; PROTEIN; PYRIN; PHOSPHORYLATION; MUTATION; CASPASES;

D O I：

10.3390/molecules26061704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

引用

页数：24

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