Comparison of two inflammation-based prognostic scores in patients with thoracic esophageal cancer undergoing chemoradiotherapy

被引：0

作者：

Zhang, Peng ^{[1
,2
,3
,4
]}

Xi, Mian ^{[1
,2
,3
,4
]}

Zhao, Lei ^{[1
,2
,3
,4
]}

Li, Qiao-Qiao ^{[1
,2
,3
,4
]}

Shen, Jing-Xian ^{[1
,2
,5
]}

Liu, Qing ^{[6
]}

Liu, Meng-Zhong ^{[1
,2
,3
,4
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Univ Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Guangdong Esophageal Canc Inst, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Dept Radiat Oncol, Ctr Canc, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Imaging Diag & Intervent Ctr, Ctr Canc, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

[6] Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Sch Publ Hlth, 651 Dongfeng Rd East, Guangzhou 510060, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期

关键词：

Chemoradiotherapy; esophageal cancer; mGPS; neutrophil/lymphocyte ratio; prognostic factor; SQUAMOUS-CELL CARCINOMA; NEUTROPHIL/LYMPHOCYTE RATIO; GASTROESOPHAGEAL CANCER; LYMPHOCYTE RATIO; LUNG-CANCER; TUMOR SITE; SURVIVAL; RESECTION; ASSOCIATION; PREDICTOR;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this study was to compare the prognostic value of the modified Glasgow Prognostic Score (mGPS) and neutrophil/lymphocyte ratio (NLR) in patients with inoperable thoracic esophageal squamous cell carcinoma (ESCC) undergoing chemoradiotherapy. A total of 212 patients undergoing chemoradiotherapy for newly diagnosed ESCC were enrolled. Complete blood counts with differential counts were obtained at the time of the diagnosis. The relationship between mGPS/NLR and other relevant clinicopathologic variables was analyzed. Overall survival (OS) and progression-free survival (PFS) were calculated. Significant prognostic factors were identified using univariate and multivariate analyses. Receiver operating characteristic curves were used to test the prognostic validity of the mGPS and NLR. Increasing values of the mGPS and NLR were associated with more advanced disease. ROC curves verified that the predictive ability of the mGPS was superior to that of the NLR (P = 0.048). Tumor location, T classification, M classification and the mGPS were independent prognostic indicators for the OS of patients with ESCC. T classification, M classification, the mGPS and platelet count were independent prognostic indicators for the PFS of patients with ESCC. In conclusion, the mGPS was superior to the NLR for prognostic prediction in patients with thoracic ESCC.

引用

页码：1764 / 1771

页数：8

共 26 条

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