CircRNAs and its relationship with gastric cancer

被引:49
作者
Fang, Xinxin [1 ,2 ,3 ]
Wen, Jing [1 ,2 ,3 ]
Sun, Mingjun [3 ,4 ]
Yuan, Yuan [1 ,2 ,4 ]
Xu, Qian [1 ,2 ,4 ]
机构
[1] China Med Univ, Tumor Etiol & Screening Dept, Canc Inst & Gen Surg, Hosp 1, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Liaoning Prov Educ Dept, Key Lab Canc Etiol & Prevent, Shenyang, Liaoning, Peoples R China
[3] China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang, Liaoning, Peoples R China
[4] Key Lab Gastrointestinal Canc Etiol & Screening, Shenyang 110001, Liaoning, Peoples R China
关键词
circRNA; gastric cancer; cell biological behaviors; diagnosis; prognosis; CIRCULAR RNA; GENE-EXPRESSION; CELL-GROWTH; IDENTIFICATION; TRANSLATION; PROGRESSION; INHIBITION; BIOGENESIS; MIGRATION; BIOMARKER;
D O I
10.7150/jca.32927
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analysis of the reported results, we find that circRNAs not only participate in the regulation of gastric cancer (GC) cell biological behaviors, such as proliferation, invasion, migration and epithelial mesenchymal transition (EMT), but also are related to the clinicopathological features of GC such as tumor differentiation, TNM stage and metastasis, etc. According to the present screening and verification results, circRNAs are suggested to be used as biomarkers for the early diagnosis and prognosis prediction of GC, and those circRNAs involved in the genesis and development of GC have the potential as novel targets for the individualized treatment of GC.
引用
收藏
页码:6105 / 6113
页数:9
相关论文
共 77 条
[1]   Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 [J].
Abdelmohsen, Kotb ;
Panda, Amaresh C. ;
Munk, Rachel ;
Grammatikakis, Ioannis ;
Dudekula, Dawood B. ;
De, Supriyo ;
Kim, Jiyoung ;
Noh, Ji Heon ;
Kim, Kyoung Mi ;
Martindale, Jennifer L. ;
Gorospe, Myriam .
RNA BIOLOGY, 2017, 14 (03) :361-369
[2]   circRNA Biogenesis Competes with Pre-mRNA Splicing [J].
Ashwal-Fluss, Reut ;
Meyer, Markus ;
Pamudurti, Nagarjuna Reddy ;
Ivanov, Andranik ;
Bartok, Osnat ;
Hanan, Mor ;
Evantal, Naveh ;
Memczak, Sebastian ;
Rajewsky, Nikolaus ;
Kadener, Sebastian .
MOLECULAR CELL, 2014, 56 (01) :55-66
[3]   Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer [J].
Chen, Jie ;
Li, Yan ;
Zheng, Qiupeng ;
Bao, Chunyang ;
He, Jian ;
Chen, Bin ;
Lyu, Dongbin ;
Zheng, Biqiang ;
Xu, Yu ;
Long, Ziwen ;
Zhou, Ye ;
Zhu, Huiyan ;
Wang, Yanong ;
He, Xianghuo ;
Shi, Yingqiang ;
Huang, Shenglin .
CANCER LETTERS, 2017, 388 :208-219
[4]   PcircRNA_finder: a software for circRNA prediction in plants [J].
Chen, Li ;
Yu, Yongyi ;
Zhang, Xinchen ;
Liu, Chen ;
Ye, Chuyu ;
Fan, Longjiang .
BIOINFORMATICS, 2016, 32 (22) :3528-3529
[5]   Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer [J].
Chen, Shijun ;
Li, Tianwen ;
Zhao, Qianfu ;
Xiao, Bingxiu ;
Guo, Junming .
CLINICA CHIMICA ACTA, 2017, 466 :167-171
[6]   Widespread and Functional RNA Circularization in Localized Prostate Cancer [J].
Chen, Sujun ;
Huang, Vincent ;
Xu, Xin ;
Livingstone, Julie ;
Soares, Fraser ;
Jeon, Jouhyun ;
Zeng, Yong ;
Hua, Junjie Tony ;
Petricca, Jessica ;
Guo, Haiyang ;
Wang, Miranda ;
Yousif, Fouad ;
Zhang, Yuzhe ;
Donmez, Nilgun ;
Ahmed, Musaddeque ;
Volik, Stas ;
Lapuk, Anna ;
Chua, Melvin L. K. ;
Heisler, Lawrence E. ;
Foucal, Adrien ;
Fox, Natalie S. ;
Fraser, Michael ;
Bhandari, Vinayak ;
Shiah, Yu-Jia ;
Guan, Jiansheng ;
Li, Jixi ;
Orain, Michele ;
Picard, Valerie ;
Hovington, Helene ;
Bergeron, Alain ;
Lacombe, Louis ;
Fradet, Yves ;
Tetu, Bernard ;
Liu, Stanley ;
Feng, Felix ;
Wu, Xue ;
Shao, Yang W. ;
Komor, Malgorzata A. ;
Sahinalp, Cenk ;
Collins, Colin ;
Hoogstrate, Youri ;
de Jong, Mark ;
Fijneman, Remond J. A. ;
Fei, Teng ;
Jenster, Guido ;
van der Kwast, Theodorus ;
Bristow, Robert G. ;
Boutros, Paul C. ;
He, Housheng Hansen .
CELL, 2019, 176 (04) :831-+
[7]   SPLICING WITH INVERTED ORDER OF EXONS OCCURS PROXIMAL TO LARGE INTRONS [J].
COCQUERELLE, C ;
DAUBERSIES, P ;
MAJERUS, MA ;
KERCKAERT, JP ;
BAILLEUL, B .
EMBO JOURNAL, 1992, 11 (03) :1095-1098
[8]   The RNA Binding Protein Quaking Regulates Formation of circRNAs [J].
Conn, Simon J. ;
Pillman, Katherine A. ;
Toubia, John ;
Conn, Vanessa M. ;
Salmanidis, Marika ;
Phillips, Caroline A. ;
Roslan, Suraya ;
Schreiber, Andreas W. ;
Gregory, Philip A. ;
Goodall, Gregory J. .
CELL, 2015, 160 (06) :1125-1134
[9]   Circular RNAs expression profiles in human gastric cancer [J].
Dang, Yuan ;
Ouyang, Xiaojuan ;
Zhang, Fan ;
Wang, Kai ;
Lin, Youdong ;
Sun, Baochang ;
Wang, Yu ;
Wang, Lie ;
Huang, Qiaojia .
SCIENTIFIC REPORTS, 2017, 7
[10]   Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation o transcription factor SOX4 [J].
Ding, Lixian ;
Zhao, Yuying ;
Dang, Shuwei ;
Wang, Yue ;
Li, Xinglong ;
Yu, Xiaotong ;
Li, Zhongsheng ;
Wei, Jiufeng ;
Liu, Ming ;
Li, Guodong .
MOLECULAR CANCER, 2019, 18 (1)