IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity

被引：47
作者：
Wang, Jinguo [1 ,2 ]
Wicker, Linda S. [3 ]
Santamaria, Pere [1 ,2 ]
机构：
[1] Univ Calgary, JMDRC, Fac Med, Inst Inflammat Infect & Immun, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Dept Microbiol & Infect Dis, Fac Med, Inst Inflammat Infect & Immun, Calgary, AB T2N 4N1, Canada
[3] Univ Cambridge, Juvenile Diabet Res Fdn, Wellcome Trust Diabet & Inflammat Lab, Dept Med Genet,Cambridge Inst Med Res, Cambridge CB2 2XY, England
来源：
SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 06期
基金：
加拿大健康研究院; 英国惠康基金;
关键词：
Type; 1; diabetes; Immunogenetics; IL-2; IL-2RA; CD4+CD25+Tregs; Immunoregulation; GENOME-WIDE ASSOCIATION; REGULATORY T-CELLS; LYMPHOID TYROSINE PHOSPHATASE; TYPE-1 DIABETES LOCUS; NATURAL-KILLER-CELLS; INTERLEUKIN-2; GENE; DENDRITIC CELLS; CUTTING EDGE; ALPHA-CHAIN; RHEUMATOID-ARTHRITIS;
D O I：
10.1016/j.smim.2009.04.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 1 diabetes (T1D) is an organ-specific autoimmune disease featured by destruction of the insulin producing beta-cells of the pancreas by autoreactive T-lymphocytes. Putative environmental triggers conspire with a constellation of genetic elements scattered throughout the genome to elicit a multifactorial autoimmune response involving virtually every cell type of the immune system against pancreatic beta-cells. Recent highly powered genome-wide association studies have confirmed and identified fifteen chromosomal regions harboring several candidate T1D-associated gene loci. Here, we summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse IL2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：363 / 371
页数：9
相关论文
共 123 条
  • [1] Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells
    Adachi, S
    Rothenberg, EV
    [J]. NUCLEIC ACIDS RESEARCH, 2005, 33 (10) : 3200 - 3210
  • [2] Homeostasis of peripheral CD4+ T cells:: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    Almeida, ARM
    Legrand, N
    Papiernik, M
    Freitas, AA
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (09) : 4850 - 4860
  • [3] Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b+CD11c- APC
    Anderson, Ana C.
    Chandwaskar, Rucha
    Lee, David H.
    Kuchroo, Vijay K.
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (11) : 7449 - 7452
  • [4] Projection of an immunological self shadow within the thymus by the aire protein
    Anderson, MS
    Venanzi, ES
    Klein, L
    Chen, ZB
    Berzins, SP
    Turley, SJ
    von Boehmer, H
    Bronson, R
    Dierich, A
    Benoist, C
    Mathis, D
    [J]. SCIENCE, 2002, 298 (5597) : 1395 - 1401
  • [5] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter
    Andrejeva, J
    Childs, KS
    Young, DF
    Carlos, TS
    Stock, N
    Goodbourn, S
    Randall, RE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) : 17264 - 17269
  • [6] Association of CTLA4 polymorphism with regulatory T cell frequency
    Atabani, SF
    Thio, CL
    Divanovic, S
    Trompette, A
    Belkaid, Y
    Thomas, DL
    Karp, CL
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (07) : 2157 - 2162
  • [7] Rentapping the insulin gene/IDDM2 locus in type 1 diabetes
    Barratt, BJ
    Payne, F
    Lowe, CE
    Hermann, R
    Healy, BC
    Harold, D
    Concannon, P
    Gharani, N
    McCarthy, MI
    Olavesen, MG
    McCormack, R
    Guja, C
    Ionescu-Tîrgoviste, C
    Undlien, DE
    Ronningen, KS
    Gillespie, KM
    Tuomilehto-Wolf, E
    Tuomilehto, J
    Bennett, ST
    Clayton, DG
    Cordell, HJ
    Todd, JA
    [J]. DIABETES, 2004, 53 (07) : 1884 - 1889
  • [8] Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Barton, Anne
    Thomson, Wendy
    Ke, Xiayi
    Eyre, Steve
    Hinks, Anne
    Bowes, John
    Plant, Darren
    Gibbons, Laura J.
    Wilson, Anthony G.
    Bax, Deborah E.
    Morgan, Ann W.
    Emery, Paul
    Steer, Sophia
    Hocking, Lynne
    Reid, David M.
    Wordsworth, Paul
    Harrison, Pille
    Worthington, Jane
    [J]. NATURE GENETICS, 2008, 40 (10) : 1156 - 1159
  • [9] Understanding quantitative genetic variation
    Barton, NH
    Keightley, PD
    [J]. NATURE REVIEWS GENETICS, 2002, 3 (01) : 11 - 21
  • [10] Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
    Bayer, AL
    Yu, AX
    Adeegbe, D
    Malek, TR
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (05) : 769 - 777
12345678910