Changes in circulating level of angiogenic factors from first to second trimester as predictors of preeclampsia

被引：147

作者：

Vatten, Lars J. ^{[1
]}

Eskild, Anne

Nilsen, Tom I. L.

Jeansson, Stig

Jenum, Pal A.

Staff, Anne Cathrine

机构：

[1] Norwegian Univ Sci & Technol, Dept Publ Hlth, N-7034 Trondheim, Norway

[2] Univ Oslo, Ulleval Hosp, Dept Obstet & Gynecol, Oslo, Norway

[3] Univ Oslo, Akershus Univ Hosp, Dept Obstet & Gynecol, N-0316 Oslo, Norway

[4] Norwegian Inst Publ Hlth, Div Mental Hlth, Oslo, Norway

[5] Univ Oslo, Ulleval Hosp, Dept Microbiol, Oslo, Norway

[6] Asker & Baerum Hosp, Dept Microbiol, Baerum, Norway

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2007年 / 196卷 / 03期

关键词：

length of pregnancy; placenta growth factor; population study; preeclampsia; soluble fms-like tyrosine kinase 1;

D O I：

10.1016/j.ajog.2006.10.909

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: This study was undertaken to assess changes in placenta growth factor and soluble fms-like tyrosine kinase-1 as predictors of preeclampsia. Study design: Nested case-control study of 154 preeclampsia cases delivered preterm and 190 delivered at term, and 392 controls. Results: Comparing the lowest and highest quartile of placenta growth factor increase from first to second trimester, the odds for preterm preeclampsia was 13.8 (95% CI, 4.4-43.2) higher for women with the lowest increase. Compared with controls, women with preterm preeclampsia had lower soluble fms-like tyrosine kinase-1 in the first, but higher in second trimester. Comparing highest and lowest quartile of increase, the odds for preterm preeclampsia was 9.2 (95% CI 3.4-25.0) higher for women with highest increase. Low placenta growth factor and high soluble fms-like tyrosine kinase-1 increase combined yielded extremely high relative risk of preterm preeclampsia (odds ratio, 35.3, 95% CI, 7.6-164.2), compared with the combination of high (placenta growth factor) and low (soluble fms-like tyrosine kinase-1) increase. Conclusion: Low placenta growth factor and high soluble fms-like tyrosine kinase-1 increase from first to second trimester are strong predictors of preeclampsia. © 2007 Mosby, Inc. All rights reserved.

引用

页码：239 / 241

页数：3

共 24 条

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