B(C6F5)3-catalyzed synthesis of coumarins via Pechmann condensation under solvent-free conditions

被引：3
|
作者：
Prajapti, Santosh Kumar [1 ]
Rao, S. Prakash [1 ]
机构：
[1] Columbia Inst Pharm, Dept Med Chem, Raipur 493111, Chhattisgarh, India
来源：
MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 04期
关键词：
Tris(pentafluorophenyl)borane; Pechmann condensation; Coumarin; Lewis acid; Solvent-free conditions; ONE-POT CONSTRUCTION; RECYCLABLE CATALYST; EFFICIENT SYNTHESIS; FRIEDEL-CRAFTS; HALOGEN-FREE; DERIVATIVES; ACID; TRIS(PENTAFLUOROPHENYL)BORANE; NANOCOMPOSITES; GREEN;
D O I：
10.1007/s00706-021-02747-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tris(pentafluorophenyl)borane [B(C6F5)(3)] catalyzed simple, efficient and environmentally benign protocol has been developed for the Pechmann condensation using variety of phenols and beta-ketoesters under solvent-free conditions to afford coumarin derivatives. The present protocol displayed significant advantages such as low catalyst loading, short reaction time, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups. In addition, it is a convenient, clean, and fast alternative approach for synthesizing variety of coumarin derivatives. Moreover, the applicability of this method towards large-scale synthesis demonstrated its suitability for the industrial application. [GRAPHICS] .
引用
收藏
页码：469 / 473
页数：5
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