RPA and RAD51: fork reversal, fork protection, and genome stability

被引：248
|
作者：
Bhat, Kamakoti P. [1 ]
Cortez, David [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2018年 / 25卷 / 06期
关键词：
REPLICATION PROTEIN-A; SINGLE-STRANDED-DNA; PROMOTES HOMOLOGOUS RECOMBINATION; ESCHERICHIA-COLI; BRCA2-DEFICIENT CELLS; MMS22L-TONSL COMPLEX; BINDING DOMAINS; REPAIR PROTEINS; NASCENT DNA; STRESS;
D O I：
10.1038/s41594-018-0075-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA translocases, and signaling proteins to control replication, repair, recombination, and the DNA damage response. Their different DNA-binding mechanisms, enzymatic activities, and binding partners provide unique functionalities that cooperate to ensure that the appropriate activities are deployed at the right time to overcome replication challenges. Here we review and discuss the latest discoveries of the mechanisms by which these proteins work to preserve genome stability, with a focus on their actions in fork reversal and fork protection.
引用
收藏
页码：446 / 453
页数：8
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