Antiepileptic drugs and brain development

被引：112
作者：
Ikonomidou, Chrysanthy [1 ,3 ]
Turski, Lechoslaw [2 ]
机构：
[1] Univ Wisconsin, Waisman Ctr, Madison, WI 53792 USA
[2] Solvay Pharmaceut Res Labs, NL-1381 CP Weesp, Netherlands
[3] Univ Wisconsin, Dept Neurol, Madison, WI 53792 USA
来源：
EPILEPSY RESEARCH | 2010年 / 88卷 / 01期
关键词：
Development; Apoptosis; Neurodegeneration; Neurogenesis; Synaptogenesis; Anticonvulsants; DEVELOPING RAT-BRAIN; PRENATAL PHENYTOIN EXPOSURE; NERVOUS-SYSTEM DEVELOPMENT; FETAL HYDANTOIN SYNDROME; INDUCED BIRTH-DEFECTS; SPINAL-CORD NEURONS; VALPROIC ACID; APOPTOTIC NEURODEGENERATION; CELL-DEATH; GRANULE CELLS;
D O I：
10.1016/j.eplepsyres.2009.09.019
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Epilepsy, the most common neurological disorder in young humans, has its highest incidence during the first year of life. Antiepileptic drugs (AEDs) which are used to treat seizures in infants, children and pregnant women target ion channels, neurotransmitters and second messenger systems in the brain. The same targets regulate brain processes essential both for propagation of seizures and for brain development, learning, memory and emotional behavior. Here we review adverse effects of AEDs in the developing mammalian brain. In addition, we discuss mechanisms explaining adverse effects of AEDs in the developing mammalian brain including interference with cell proliferation and migration, neurogenesis, axonal. arborization, synaptogenesis, synaptic plasticity and physiological apoptotic cell death. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：11 / 22
页数：12
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