Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity

被引：28

作者：

Chou, Po-Han ^{[1
,2
,3
,4
]}

Lin, Yen-Feng ^{[4
,5
,6
,7
]}

Lu, Ming-Kuei ^{[8
,9
]}

Chang, Hsin-An ^{[10
]}

Chu, Che-Sheng ^{[11
,12
,13
]}

Chang, Wei Hung ^{[14
,15
]}

Kishimoto, Taishiro ^{[16
]}

Sack, Alexander T. ^{[17
,18
]}

Su, Kuan-Pin ^{[2
,19
,20
,21
]}

机构：

[1] China Med Univ, Hsinchu Hosp, Dept Psychiat, Hsinchu, Taiwan

[2] China Med Univ, China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan

[3] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan

[4] Taiwan Allied Clin Integrat TMS, Taipei, Taiwan

[5] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Taiwan

[6] Natl Yang Ming Chiao Tung Univ, Fac Med, Dept Publ Hlth & Med Humanities, Taipei, Taiwan

[7] Balance Psychiat Clin, Hsinchu, Taiwan

[8] China Med Univ, Coll Med, PhD Program Translat Med, Taichung, Taiwan

[9] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[10] Natl Def Med Ctr, Triserv Gen Hosp, Dept Psychiat, Taipei, Taiwan

[11] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan

[12] Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol, Kaohsiung, Taiwan

[13] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[14] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, Tainan, Taiwan

[15] Natl Cheng Kung Univ Hosp, Dept Psychiat, Dou Liou Branch, Touliu, Yunlin, Taiwan

[16] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[17] Maastricht Univ, Fac Psychol & Neurosci, Dept Cognit Neurosci, Maastricht, Netherlands

[18] Maastricht Univ, Brain Nerve Ctr, Sch Mental Hlth & Neurosci MHeNs, Dept Psychiat & Neuropsychol,Med Ctr MUMC, Maastricht, Netherlands

[19] China Med Univ, Coll Med, Taichung, Taiwan

[20] China Med Univ Hosp, Mind Body Interface Lab MBI Lab, Taichung, Taiwan

[21] China Med Univ, An Nan Hosp, Tainan, Taiwan

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2021年 / 19卷 / 02期

关键词：

Depression; Brain stimulation; Repetitive transcranial magnetic stimulation; rTMS; Theta-burst stimulation; TBS; THETA-BURST STIMULATION; POSTTRAUMATIC-STRESS-DISORDER; DORSOLATERAL PREFRONTAL CORTEX; HEART-RATE-VARIABILITY; DOUBLE-BLIND; RTMS TREATMENT; ANTIDEPRESSANT EFFICACY; NETWORK METAANALYSIS; THERAPEUTIC-EFFICACY; RESISTANT DEPRESSION;

D O I：

10.9758/cpn.2021.19.2.190

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.

引用

页码：190 / 205

页数：16