Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)

被引：32

作者：

Feketea, Gavriela ^{[1
,2
]}

Vlacha, Vasiliki ^{[3
]}

Bocsan, Ioana Corina ^{[4
]}

Vassilopoulou, Emilia ^{[5
]}

Stanciu, Luminita Aurelia ^{[6
]}

Zdrenghea, Mihnea ^{[1
,7
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Hematol, Cluj Napoca, Romania

[2] Karamandaneio Children Hosp, Dept Pediat, Pediat Allergy Outpatient Clin, Patras, Greece

[3] Univ Ioannina, Dept Early Years Learning & Care, Ioannina, Greece

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca, Romania

[5] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece

[6] Imperial Coll London, Natl Heart & Lung Inst, London, England

[7] Ion Chiricuta Oncol Inst, Cluj Napoca, Romania

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

vitamin D; 25(OH)D3; SARS-CoV-2; infection; COVID-19; multisystem; Kawasaki syndrome-like; KAWASAKI-LIKE DISEASE; D SUPPLEMENTATION; D DEFICIENCY; INFLUENZA-A; RISK; CELLS;

D O I：

10.3389/fimmu.2021.648546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regarding the outcome of MIS-C. Vitamin D could be a potential candidate. In this mini review we analyze the immunomodulatory role of vitamin D in viral infections and specifically in COVID-19. We also examine the current literature regarding the association of vitamin D with MIS-C and Kawasaki disease. The vitamin D was evaluated not only as a biomarker but also as a nutritional supplement. We concluded that vitamin D levels could be valuable in predicting severe forms of MIS-C and correction of abnormal levels in severe MIS-C may influences its evolution. 25-hydroxyvitamin D3 [25(OH)D3] supplementation raising serum [25(OH)D] concentrations potentially have a favorable effect in reducing the severity of MIS-C in certain circumstances. Further studies are needed to confirm these results.

引用

页数：7

共 60 条

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