Depigmenting Effect of Catechins

被引：57

作者：

Sato, Kazuomi ^{[1
]}

Toriyama, Masaru ^{[2
]}

机构：

[1] Tamagawa Univ, Coll Agr, Dept Life Sci, Tokyo 1948610, Japan

[2] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Shizuoka 4228529, Japan

来源：

MOLECULES | 2009年 / 14卷 / 11期

关键词：

catechin; gallic acid; melanogenesis; B16; melanoma; tyrosinase; alpha-MSH (alpha-melanocyte stimulating hormone); TYROSINASE-RELATED PROTEIN; DOPACHROME TAUTOMERASE; GREEN TEA; CELLS; INDUCTION; MELANOMA; GROWTH; TRP-2; EGCG;

D O I：

10.3390/molecules14114425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To elucidate the anti-melanogenic mechanism of the catechin group, we performed Western blotting analysis for crucial melanogenic protein, namely tyrosinase. The catechin group inhibited tyrosinase expression. These results indicate that the catechin group is a candidate anti-melanogenic agent and that it might be effective in hyperpigmentation disorders.

引用

页码：4425 / 4432

页数：8

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