Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

被引：373

作者：

Yoon, Sung-Han ^{[1
]}

Bleiziffer, Sabine ^{[2
]}

De Backer, Ole ^{[3
]}

Delgado, Victoria ^{[4
]}

Arai, Takahide ^{[5
]}

Ziegelmueller, Johannes ^{[2
]}

Barbanti, Marco ^{[6
]}

Sharma, Rahul ^{[1
]}

Perlman, Gidon Y. ^{[7
]}

Khalique, Omar K. ^{[8
]}

Holy, Erik W. ^{[9
,10
]}

Saraf, Smriti ^{[11
]}

Deuschl, Florian ^{[12
]}

Fujita, Buntaro ^{[13
]}

Ruile, Philipp ^{[14
]}

Neumann, Franz-Josef ^{[15
]}

Pache, Gregor ^{[15
]}

Takahashi, Masao ^{[16
]}

Kaneko, Hidehiro ^{[17
]}

Schmidt, Tobias ^{[18
]}

Ohno, Yohei ^{[7
]}

Schofer, Niklas ^{[12
]}

Kong, William K. F. ^{[4
,19
]}

Tay, Edgar ^{[19
]}

Sugiyama, Daisuke ^{[20
]}

Kawamori, Hiroyuki ^{[1
]}

Maeno, Yoshio ^{[1
]}

Abramowitz, Yigal ^{[1
]}

Chakravarty, Tarun ^{[1
]}

Nakamura, Mamoo ^{[1
]}

Kuwata, Shingo ^{[21
]}

Yong, Gerald ^{[22
]}

Kao, Hsien-Li ^{[23
]}

Lee, Michael ^{[24
]}

Kim, Hyo-Soo ^{[25
,26
]}

Modine, Thomas ^{[27
]}

Wong, S. Chiu ^{[28
]}

Bedgoni, Francesco ^{[29
]}

Testa, Luca ^{[29
]}

Teiger, Emmanuel ^{[16
]}

Butter, Christian ^{[17
]}

Ensminger, Stephan M. ^{[13
]}

Schaefer, Ulrich ^{[12
]}

Dvir, Danny ^{[7
]}

Blanke, Philipp ^{[7
]}

Leipsic, Jonathon ^{[7
]}

Nietlispach, Fabian ^{[21
]}

Abdel-Wahab, Mohamed ^{[9
,10
]}

Chevalier, Bernard ^{[5
]}

Tamburino, Corrado ^{[6
]}

机构：

[1] Cedars Sinai Heart Inst, Dept Intervent Cardiol, 8700 Beverly Blvd, Los Angeles, CA 90048 USA

[2] German Heart Ctr Munich, Clin Cardiovasc Surg, Munich, Germany

[3] Univ Hosp, Rigshosp, Heart Ctr, Copenhagen, Denmark

[4] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands

[5] Hop Prive Jacques Cartier, Inst Cardiovasc Paris Sud, Gen Sante, Massy, France

[6] Univ Catania, Ferrarotto Hosp, Div Cardiol, Catania, Italy

[7] Univ British Columbia, St Pauls Hosp, Dept Cardiol, Vancouver, BC, Canada

[8] Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USA

[9] Univ Kiel, Acad Teaching Hosp, Segeberger Kliniken GmbH, Heart Ctr, Hamburg, Germany

[10] Univ Kiel, Acad Teaching Hosp, Segeberger Kliniken GmbH, Heart Ctr, Lubeck, Germany

[11] Brighton & Sussex Univ Hosp NHS Trust, Sussex Cardiac Ctr, Brighton, E Sussex, England

[12] Univ Heart Ctr, Dept Gen & Intervent Cardiol, Hamburg, Germany

[13] Ruhr Univ Bochum, Dept Thorac & Cardiovasc Surg, Heart & Diabet Ctr NRW, Bad Oeynhausen, Germany

[14] Univ Heart Ctr Freiburg Bad Krozingen, Dept Cardiol & Angiol 2, Bad Krozingen, Germany

[15] Univ Freiburg, Sect Cardiovasc Radiol, Dept Radiol, Bad Krozingen, Germany

[16] Henri Mondor Univ Hosp, Dept Cardiol, Creteil, France

[17] Heart Ctr Brandenburg Bernau, Bernau, Germany

[18] Asklepios Klink St Georg, Dept Cardiol, Hamburg, Germany

[19] Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore

[20] Keio Univ, Dept Prevent Med & Publ Hlth, Tokyo, Japan

[21] Univ Zurich Hosp, Univ Heart Ctr, Zurich, Switzerland

[22] Royal Perth Hosp, Div Cardiol, Perth, WA, Australia

[23] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[24] Queen Elizabeth Hosp, Div Cardiol, Kowloon, Hong Kong, Peoples R China

[25] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[26] Seoul Natl Univ Hosp, Cardiovasc Ctr, Seoul, South Korea

[27] Hosp Cardiol, Dept Cardiovasc Surg, Lille, France

[28] New York Presbyterian Hosp, Weil Cornell Med, Greenberg Div Cardiol, New York, NY USA

[29] IRCCS Pol San Donato, Dept Cardiol, Milan, Italy

[30] Intermt Heart Inst, Div Cardiovasc Dis, Salt Lake City, UT USA

[31] Univ Ulsan, Asan Med Ctr, Div Cardiol, Seoul, South Korea

[32] EMO GVM Ctr Cuore Columbus, Intervent Cardiol Unit, Milan, Italy

[33] Ist Sci San Raffaele, Milan, Italy

[34] Osped San Raffaele, Milan, Italy

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2017年 / 69卷 / 21期

关键词：

aortic stenosis; bicuspid aortic valve; transcatheter aortic valve implantation; HIGH-RISK PATIENTS; EDWARDS SAPIEN VALVE; HEART-VALVE; IMPLANTATION; REGURGITATION; SURGERY; CLASSIFICATION; COMPLICATIONS; FEASIBILITY; MULTICENTER;

D O I：

10.1016/j.jacc.2017.03.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS). OBJECTIVES This study sought to compare the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS from the Bicuspid AS TAVR multicenter registry. METHODS Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity score matching, assembling 546 pairs of patients with similar baseline characteristics. Procedural and clinical outcomes were recorded according to Valve Academic Research Consortium-2 criteria. RESULTS Compared with patients with tricuspid AS, patients with bicuspid AS had more frequent conversion to surgery (2.0% vs. 0.2%; p = 0.006) and a significantly lower device success rate (85.3% vs. 91.4%; p = 0.002). Early-generation devices were implanted in 320 patients with bicuspid and 321 patients with tricuspid AS, whereas new-generation devices were implanted in 226 and 225 patients with bicuspid and tricuspid AS, respectively. Within the group receiving early-generation devices, bicuspid AS had more frequent aortic root injury (4.5% vs. 0.0%; p = 0.015) when receiving the balloon-expanding device, and moderate-to-severe paravalvular leak (19.4% vs. 10.5%; p = 0.02) when receiving the self-expanding device. Among patients with new-generation devices, however, procedural results were comparable across different prostheses. The cumulative all-cause mortality rates at 2 years were comparable between bicuspid and tricuspid AS (17.2% vs. 19.4%; p = 0.28). CONCLUSIONS Compared with tricuspid AS, TAVR in bicuspid AS was associated with a similar prognosis, but lower device success rate. Procedural differences were observed in patients treated with the early-generation devices, whereas no differences were observed with the new-generation devices. (J Am Coll Cardiol 2017;69: 2579-89) (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：2579 / 2589

页数：11

共 32 条

[11] A Bicuspid Aortic Valve Imaging Classification for the TAVR Era [J].

Jilaihawi, Hasan ;

Chen, Mao ;

Webb, John ;

Himbert, Dominique ;

Ruiz, Carlos E. ;

Rodes-Cabau, Josep ;

Pache, Gregor ;

Colombo, Antonio ;

Nickenig, Georg ;

Lee, Michael ;

Tamburino, Corrado ;

Sievert, Horst ;

Abramowitz, Yigal ;

Tarantini, Giuseppe ;

Alqoofi, Faisal ;

Chakravarty, Tarun ;

Kashif, Mohammad ;

Takahashi, Nobuyuki ;

Kazuno, Yoshio ;

Maeno, Yoshio ;

Kawamori, Hiroyuki ;

Chieffo, Alaide ;

Blanke, Philipp ;

Dvir, Danny ;

Ribeiro, Henrique Barbosa ;

Feng, Yuan ;

Zhao, Zhen-Gang ;

Sinning, Jan-Malte ;

Kliger, Chad ;

Giustino, Gennaro ;

Pajerski, Basia ;

Imme, Sebastiano ;

Grube, Eberhard ;

Leipsic, Jonathon ;

Vahanian, Alec ;

Michev, Iassen ;

Jelnin, Vladimir ;

Latib, Azeem ;

Cheng, Wen ;

Makkar, Raj .

JACC-CARDIOVASCULAR IMAGING, 2016, 9 (10) :1145-1158

[12]

Kappetein AP, 2012, J AM COLL CARDIOL, V60, P1438, DOI [10.1093/ejcts/ezs533, 10.1016/j.jacc.2012.09.001]

[13] Paravalvular regurgitation after transcatheter aortic valve replacement with the Edwards sapien valve in the PARTNER trial: characterizing patients and impact on outcomes [J].

Kodali, Susheel ;

Pibarot, Philippe ;

Douglas, Pamela S. ;

Williams, Mathew ;

Xu, Ke ;

Thourani, Vinod ;

Rihal, Charanjit S. ;

Zajarias, Alan ;

Doshi, Darshan ;

Davidson, Michael ;

Tuzcu, E. Murat ;

Stewart, William ;

Weissman, Neil J. ;

Svensson, Lars ;

Greason, Kevin ;

Maniar, Hersh ;

Mack, Michael ;

Anwaruddin, Saif ;

Leon, Martin B. ;

Hahn, Rebecca T. .

EUROPEAN HEART JOURNAL, 2015, 36 (07) :449-+

[14] Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients [J].

Leon, Martin B. ;

Smith, Craig R. ;

Mack, Michael J. ;

Makkar, Raj R. ;

Svensson, Lars G. ;

Kodali, Susheel K. ;

Thourani, Vinod H. ;

Tuzcu, E. Murat ;

Miller, D. Craig ;

Herrmann, Howard C. ;

Doshi, Darshan ;

Cohen, David J. ;

Pichard, Augusto D. ;

Kapadia, Samir ;

Dewey, Todd ;

Babaliaros, Vasilis ;

Szeto, Wilson Y. ;

Williams, Mathew R. ;

Kereiakes, Dean ;

Zajarias, Alan ;

Greason, Kevin L. ;

Whisenant, Brian K. ;

Hodson, Robert W. ;

Moses, Jeffrey W. ;

Trento, Alfredo ;

Brown, David L. ;

Fearon, William F. ;

Pibarot, Philippe ;

Hahn, Rebecca T. ;

Jaber, Wael A. ;

Anderson, William N. ;

Alu, Maria C. ;

Webb, John G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (17) :1609-1620

[15] Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery. [J].

Leon, Martin B. ;

Smith, Craig R. ;

Mack, Michael ;

Miller, D. Craig ;

Moses, Jeffrey W. ;

Svensson, Lars G. ;

Tuzcu, E. Murat ;

Webb, John G. ;

Fontana, Gregory P. ;

Makkar, Raj R. ;

Brown, David L. ;

Block, Peter C. ;

Guyton, Robert A. ;

Pichard, Augusto D. ;

Bavaria, Joseph E. ;

Herrmann, Howard C. ;

Douglas, Pamela S. ;

Petersen, John L. ;

Akin, Jodi J. ;

Anderson, William N. ;

Wang, Duolao ;

Pocock, Stuart .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (17) :1597-1607

[16] Outcomes Following Transcatheter Aortic Valve Replacement in the United States [J].

Mack, Michael J. ;

Brennan, J. Matthew ;

Brindis, Ralph ;

Carroll, John ;

Edwards, Fred ;

Grover, Fred ;

Shahian, David ;

Tuzcu, E. Murat ;

Peterson, Eric D. ;

Rumsfeld, John S. ;

Hewitt, Kathleen ;

Shewan, Cynthia ;

Michaels, Joan ;

Christensen, Barb ;

Christian, Alexander ;

O'Brien, Sean ;

Holmes, David .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (19) :2069-2077

[17] Incidence of Aortic Complications in Patients With Bicuspid Aortic Valves [J].

Michelena, Hector I. ;

Khanna, Amber D. ;

Mahoney, Douglas ;

Margaryan, Edit ;

Topilsky, Yan ;

Suri, Rakesh M. ;

Eidem, Ben ;

Edwards, William D. ;

Sundt, Thoralf M., III ;

Enriquez-Sarano, Maurice .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (10) :1104-1112

[18] Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Disease [J].

Mylotte, Darren ;

Lefevre, Thierry ;

Sondergaard, Lars ;

Watanabe, Yusuke ;

Modine, Thomas ;

Dvir, Danny ;

Bosmans, Johan ;

Tchetche, Didier ;

Kornowski, Ran ;

Sinning, Jan-Malte ;

Theriault-Lauzier, Pascal ;

O'Sullivan, Crochan J. ;

Barbanti, Marco ;

Debry, Nicolas ;

Buithieu, Jean ;

Codner, Pablo ;

Dorfmeister, Magdalena ;

Martucci, Giuseppe ;

Nickenig, Georg ;

Wenaweser, Peter ;

Tamburino, Corrado ;

Grube, Eberhard ;

Webb, John G. ;

Windecker, Stephan ;

Lange, Ruediger ;

Piazza, Nicolo .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (22) :2330-2339

[19] Bicuspid Aortic Valve Stenosis Favorable Early Outcomes With a Next-Generation Transcatheter Heart Valve in a Multicenter Study [J].

Perlman, Gidon Y. ;

Blanke, Philipp ;

Dvir, Danny ;

Pache, Gregor ;

Modine, Thomas ;

Barbanti, Marco ;

Holy, Erik W. ;

Treede, Hendrik ;

Ruile, Philipp ;

Neumann, Franz-Josef ;

Gandolfo, Caterina ;

Saia, Francesco ;

Tamburino, Corrado ;

Mak, George ;

Thompson, Christopher ;

Wood, David ;

Leipsic, Jonathon ;

Webb, John G. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2016, 9 (08) :817-824

[20] The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities [J].

Pocock, Stuart J. ;

Ariti, Cono A. ;

Collier, Timothy J. ;

Wang, Duolao .

EUROPEAN HEART JOURNAL, 2012, 33 (02) :176-182

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