Synthesis of Thiazolidine and Thiophene Derivatives for Evaluation as Anticancer Agents

被引：42

作者：

El-Gaby, M. S. A. ^{[1
]}

Ismail, Z. H. ^{[1
]}

Abdel-Gawad, S. M. ^{[2
]}

Aly, H. M. ^{[2
]}

Ghorab, M. M. ^{[3
]}

机构：

[1] Al Azhar Univ Assiut, Dept Chem, Fac Sci, Assiut 71524, Egypt

[2] Al Azhar Univ, Fac Sci Girls, Dept Chem, Cairo, Egypt

[3] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Nasr City, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 10期

关键词：

1,2,5-Thiadiazole; thiazolidine and thiophene derivatives; ANTIFUNGAL ACTIVITY; BIOLOGICAL-ACTIVITY; INHIBITORS; SULFONAMIDES;

D O I：

10.1080/10426500802561096

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The non-isolated adducts (3a,b) were used as key intermediates to synthesize some novel thiazolidine and thiophene derivatives. Compound (4) exhibited a remarkable antitumor activity against EAC cells compared with the Doxorubicin as a positive control.

引用

页码：2645 / 2654

页数：10

共 20 条

[11] RELATIONS BETWEEN STRUCTURE AND BIOLOGICAL-ACTIVITY OF SULFONAMIDES [J].

MAREN, TH .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1976, 16 :309-327

[12]

Raffa Demetrio, 2004, Farmaco (Lausanne), V59, P215, DOI 10.1016/j.farmac.2003.10.004

[13] A convenient synthesis of polyfunctionally substituted 2-(aroyl-(arylsulfonyl)-methylene)-2,3-dihydrothiazoles and -thiazolidin-4-ones and their fused derivatives [J].

Sherif, SM .

MONATSHEFTE FUR CHEMIE, 1996, 127 (05) :557-568

[14] Synthesis and anticancer, antiinflammatory, and analgesic activity evaluation of some sulfa drug and acridine derivatives [J].

Sondhi, SM ;

Johar, M ;

Singhal, N ;

Dastidar, SG ;

Shukla, R ;

Raghubir, R .

MONATSHEFTE FUR CHEMIE, 2000, 131 (05) :511-520

[15] Comparison of the ocular beta-blockers [J].

Sorensen, SJ ;

Abel, SR .

ANNALS OF PHARMACOTHERAPY, 1996, 30 (01) :43-54

[16] Synthesis of aryloxy-substituted 1,2,5-thiadiazoles by the Ullmann reaction [J].

Strunskaya, EI ;

Bredikhina, ZA ;

Azancheev, NM ;

Bredikhin, AA .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2001, 37 (09) :1330-1334

[17] Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I [J].

Supuran, CT ;

Scozzafava, A ;

Jurca, BC ;

Ilies, MA .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (02) :83-93

[18] THE CYTO-TOXIC AND CYTOSTATIC EFFECTS OF THE BITTER MELON (MOMORDICA-CHARANTIA) ON HUMAN-LYMPHOCYTES [J].

TAKEMOTO, DJ ;

DUNFORD, C ;

MCMURRAY, MM .

TOXICON, 1982, 20 (03) :593-599

[19] SYNTHESIS OF BETA-ADRENERGIC BLOCKING-AGENT TIMOLOL FROM OPTICALLY-ACTIVE PRECURSORS [J].

WEINSTOCK, LM ;

MULVEY, DM ;

TULL, R .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (19) :3121-3124

[20]

YOON HJ, 2001, INT J IND ENTOMOL, V2, P37

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