Synthesis of Thiazolidine and Thiophene Derivatives for Evaluation as Anticancer Agents

被引：41
作者：
El-Gaby, M. S. A. [1 ]
Ismail, Z. H. [1 ]
Abdel-Gawad, S. M. [2 ]
Aly, H. M. [2 ]
Ghorab, M. M. [3 ]
机构：
[1] Al Azhar Univ Assiut, Dept Chem, Fac Sci, Assiut 71524, Egypt
[2] Al Azhar Univ, Fac Sci Girls, Dept Chem, Cairo, Egypt
[3] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Nasr City, Cairo, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 10期
关键词：
1,2,5-Thiadiazole; thiazolidine and thiophene derivatives; ANTIFUNGAL ACTIVITY; BIOLOGICAL-ACTIVITY; INHIBITORS; SULFONAMIDES;
D O I：
10.1080/10426500802561096
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The non-isolated adducts (3a,b) were used as key intermediates to synthesize some novel thiazolidine and thiophene derivatives. Compound (4) exhibited a remarkable antitumor activity against EAC cells compared with the Doxorubicin as a positive control.
引用
收藏
页码：2645 / 2654
页数：10
相关论文
共 20 条
[1]   Synthesis and radiation stability of some new biologically active hydroquinoline and pyrimido[4,5-b]quinoline derivatives [J].
Abdel-Gawad, SM ;
El-Gaby, MSA ;
Heiba, HI ;
Aly, HM ;
Ghorab, MM .
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2005, 52 (06) :1227-1236
[2]   Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines, pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2′,3′:4,5]thiazolo[2,3-b]quinazolines [J].
Abdel-Gawad, SM ;
El-Gaby, MSA ;
Ghorab, MM .
FARMACO, 2000, 55 (04) :287-292
[3]   Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders [J].
Cao, Y ;
Zhang, MJ ;
Wu, C ;
Lee, S ;
Wroblewski, ME ;
Whipple, T ;
Nagy, PI ;
Takács-Novák, K ;
Balázs, A ;
Törös, S ;
Messer, WS .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (20) :4273-4286
[4]   Synthesis and biological activity of some novel thieno[2,3-b]quinoline, quinolino[3',2':4,5] thieno[3,2-d]pyrimidine and pyrido[2',3':4,5] thieno[2,3-b]quinoline derivatives [J].
El-Gaby, MSA ;
Abdel-Gawad, SM ;
Ghorab, MM ;
Heiba, HI ;
Aly, HM .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2006, 181 (02) :279-297
[5]   Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties [J].
El-Gaby, MSA ;
Gaber, AM ;
Atalla, AA ;
Al-Wahab, KAA .
FARMACO, 2002, 57 (08) :613-617
[6]   BIOASSAY OF ANTI-MITOTIC ALKALOIDS OF CATHARANTHUS-ROSEUS [J].
ELMERZABANI, MM ;
ELAASER, AA ;
ELDUWEINI, AK ;
ELMASRY, AM .
PLANTA MEDICA, 1979, 36 (01) :87-90
[7]   SCREENING SYSTEM FOR EGYPTIAN PLANTS WITH POTENTIAL ANTI-TUMOUR ACTIVITY [J].
ELMERZABANI, MM ;
ELAASER, AA ;
ATTIA, MA ;
ELDUWEINI, AK ;
GHAZAL, AM .
PLANTA MEDICA, 1979, 36 (02) :150-155
[8]   Synthesis and evaluation of some new fluorinated hydroquinazoline derivatives as antifungal agents [J].
Ghorab, MM ;
Abdel-Gawad, SM ;
El-Gaby, MSA .
FARMACO, 2000, 55 (04) :249-255
[9]   THIADIAZOLE DERIVATIVES - HIGHLY POTENT AND SPECIFIC HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS [J].
HANASAKI, Y ;
WATANABE, H ;
KATSUURA, K ;
TAKAYAMA, H ;
SHIRAKAWA, S ;
YAMAGUCHI, K ;
SAKAI, S ;
IJICHI, K ;
FUJIWARA, M ;
KONNO, K ;
YOKOTA, T ;
SHIGETA, S ;
BABA, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (12) :2038-2040
[10]   1,2-DIARYLCYCLOPENTENES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS [J].
LI, JJ ;
ANDERSON, GD ;
BURTON, EG ;
COGBURN, JN ;
COLLINS, JT ;
GARLAND, DJ ;
GREGORY, SA ;
HUANG, HC ;
ISAKSON, PC ;
KOBOLDT, CM ;
LOGUSCH, EW ;
NORTON, MB ;
PERKINS, WE ;
REINHARD, EJ ;
SEIBERT, K ;
VEENHUIZEN, AW ;
ZHANG, Y ;
REITZ, DB .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (22) :4570-4578
12