Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma

被引:96
作者
Lee, Ho-Yeop [1 ,2 ,3 ]
Nga, Ha Thi [1 ,2 ,3 ]
Tian, Jingwen [1 ,2 ,3 ]
Yi, Hyon-Seung [1 ,2 ,3 ]
机构
[1] Chungnam Natl Univ, Lab Endocrinol & Immune Syst, Sch Med, Daejeon 35015, South Korea
[2] Chungnam Natl Univ, Dept Med Sci, Sch Med, Daejeon 35015, South Korea
[3] Chungnam Natl Univ, Res Ctr Endocrine & Metab Dis, Sch Med, Daejeon 35015, South Korea
基金
新加坡国家研究基金会;
关键词
hepatocellular carcinoma; mitochondria; mitochondrial unfolded protein response; glycolysis; mitoribosome; DIFFERENTIATION FACTOR 15; HEPATIC STELLATE CELLS; UNFOLDED PROTEIN RESPONSE; OXIDATIVE-PHOSPHORYLATION; COPY NUMBER; PPAR-ALPHA; ENERGY-METABOLISM; LIPID-METABOLISM; TUMOR-GROWTH; HEXOKINASE;
D O I
10.3390/cells10081901
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. HCC progression and metastasis are closely related to altered mitochondrial metabolism, including mitochondrial stress responses, metabolic reprogramming, and mitoribosomal defects. Mitochondrial oxidative phosphorylation (OXPHOS) defects and reactive oxygen species (ROS) production are attributed to mitochondrial dysfunction. In response to oxidative stress caused by increased ROS production, misfolded or unfolded proteins can accumulate in the mitochondrial matrix, leading to initiation of the mitochondrial unfolded protein response (UPRmt). The mitokines FGF21 and GDF15 are upregulated during UPRmt and their levels are positively correlated with liver cancer development, progression, and metastasis. In addition, mitoribosome biogenesis is important for the regulation of mitochondrial respiration, cell viability, and differentiation. Mitoribosomal defects cause OXPHOS impairment, mitochondrial dysfunction, and increased production of ROS, which are associated with HCC progression in mouse models and human HCC patients. In this paper, we focus on the role of mitochondrial metabolic signatures in the development and progression of HCC. Furthermore, we provide a comprehensive review of cell autonomous and cell non-autonomous mitochondrial stress responses during HCC progression and metastasis.
引用
收藏
页数:15
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