Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells

被引：1

作者：

Boutanaev, Alexander M. ^{[1
]}

Mikhaylova, Lyudmila M. ^{[1
]}

Nurminsky, Dmitry I. ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Boston, MA 02111 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 09期

关键词：

testes; transcription; somatic cells; Ku heterodimer;

D O I：

10.1016/j.febslet.2007.03.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Drosophila, developing germline cysts in testis are enveloped by two somatic cyst cells essential for germline development and male reproduction. The cyst cells continue development along with the germline. However, the mechanisms of somatic gene expression in testes are poorly understood. We report transcriptional up-regulation of the Ku heterodimer in cyst cells. The initial up-regulation is independent of germline, and transcription is further augmented during spermatogenesis. Abundance of Ku in the cyst cell cytoplasm suggests the role for Ku subunits in the regulation of sperm individualization. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1707 / 1715

页数：9

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