Clinical Manifestations and Longterm Outcome for Patients with Takayasu Arteritis in China

被引:94
作者
Yang, Lirui [1 ,2 ,3 ,4 ]
Zhang, Huimin [1 ,2 ,3 ,4 ]
Jiang, Xiongjing [1 ,2 ,3 ,4 ]
Zou, Yubao [1 ,2 ,3 ,4 ]
Qin, Fang [1 ,2 ,3 ,4 ]
Song, Lei [1 ,2 ,3 ,4 ]
Guan, Ting [1 ,2 ,3 ,4 ]
Wu, Haiying [1 ,2 ,3 ,4 ]
Xu, Lianjun [1 ,2 ,3 ,4 ]
Liu, Yaxin [1 ,2 ,3 ,4 ]
Zhou, Xianliang [1 ,2 ,3 ,4 ]
Bian, Jin [1 ,2 ,3 ,4 ]
Hui, Rutai [1 ,2 ,3 ,4 ]
Zheng, Deyu [1 ,2 ,3 ,4 ]
机构
[1] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Div Hypertens, Beijing 100037, Peoples R China
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Fuwai Hosp, State Key Lab Cardiovasc Dis, Div Hypertens, Beijing, Peoples R China
[4] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China
关键词
TAKAYASU ARTERITIS; ANGIOGRAPHY; RENAL ARTERY; CORONARY ARTERY; PULMONARY ARTERY; SYSTEMIC VASCULITIDES; ANGIOGRAPHIC FINDINGS; JAPANESE PATIENTS; PULMONARY-ARTERY; DISEASE; FEATURES; PROGNOSIS; ANTIGEN;
D O I
10.3899/jrheum.140664
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To describe a large cohort of patients with Takayasu arteritis in China. Methods. We retrospectively analyzed 566 patients hospitalized in Fuwai Hospital between 2002 and 2013. Data collected were clinical characteristics, laboratory findings, angiographic features, treatment, and longterm outcome. Results. The female to male ratio was 3.8 to 1, and the mean age of onset was 28.9 +/- 12.0 years. The most common inflammatory symptom, initial symptom, and coexisting disease were fever (52, 9.2%), dizziness (214, 37.8%), and hypertension (HTN; 392, 69.3%), respectively. Pulmonary artery, coronary artery involvement, and aortic regurgitation were found in 83 (14.7%), 66 (11.7%), and 181 (36.7%) patients, respectively. Elevation of the erythrocyte sedimentation rate was observed in 131 patients (23.1%). Treatment included drugs, interventional therapy, autologous blood vessel transplant, artificial blood vessel transplant, and aortic valve replacement. During a mean followup of 5.0 +/- 0.2 years, 32 patients died, including 1 patient who died suddenly during coronary angiography. HTN, major complications, and a progressive disease course were significant prognostic markers. Conclusion. HTN, rather than fever, is the leading reason for patients with Takayasu arteritis to see a doctor in China. HTN, major complications, and a progressive disease course are statistically significant predictors of survival. Because of cardiovascular events associated with the disease, early diagnosis and treatment are urgent to improve prognosis.
引用
收藏
页码:2439 / 2446
页数:8
相关论文
共 32 条
[1]  
AREND WP, 1990, ARTHRITIS RHEUM, V33, P1129
[2]   Takayasu Arteritis in France A Single-Center Retrospective Study of 82 Cases Comparing White, North African, and Block Patients [J].
Arnaud, Laurent ;
Haroche, Julien ;
Limal, Nicolas ;
Toledano, Dan ;
Gambotti, Laetitia ;
Chalumeau, Nathalie Costedoat ;
Boutin, Du Le Thi Huong ;
Cacoub, Patrice ;
Cluzel, Philippe ;
Koskas, Fabien ;
Kieffer, Edouard ;
Piette, Jean-Charles ;
Amoura, Zahir .
MEDICINE, 2010, 89 (01) :1-17
[3]  
Bicakcigil M, 2009, CLIN EXP RHEUMATOL, V27, pS59
[4]   TAKAYASUS ARTERITIS - ANGIOGRAPHIC STUDY WITH REMARKS ON ETHNIC DISTRIBUTION IN ISRAEL [J].
DEUTSCH, V ;
WEXLER, L ;
DEUTSCH, H .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1974, 122 (01) :13-28
[5]   Takayasu's Disease in the center of Tunisia: 27 cases [J].
Jaafoura, N. Ghannouchi ;
Khalifa, M. ;
Rezgui, A. ;
Alaoua, A. ;
Ben Jazia, E. ;
Braham, A. ;
Kechrid, C. ;
Mahjoub, S. ;
Ernez, S. ;
Boughzela, E. ;
Ben Farhat, M. ;
Letaief, A. ;
Bahri, F. .
JOURNAL DES MALADIES VASCULAIRES, 2010, 35 (01) :4-11
[6]   TAKAYASU ARTERITIS - A STUDY OF 32 NORTH-AMERICAN PATIENTS [J].
HALL, S ;
BARR, W ;
LIE, JT ;
STANSON, AW ;
KAZMIER, FJ ;
HUNDER, GG .
MEDICINE, 1985, 64 (02) :89-99
[7]   Surrogate markers of disease activity in patients with Takayasu arteritis - A preliminary report from The International Network for the Study of the Systemic Vasculitides (INSSYS) [J].
Hoffman, GS ;
Ahmed, AE .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1998, 66 :S191-S194
[8]  
Hoffman GS, 1998, INT J CARDIOL, V66, pS195
[9]   LONG-TERM OUTCOME FOR 120 JAPANESE PATIENTS WITH TAKAYASUS-DISEASE - CLINICAL AND STATISTICAL-ANALYSES OF RELATED PROGNOSTIC FACTORS [J].
ISHIKAWA, K ;
MAETANI, S .
CIRCULATION, 1994, 90 (04) :1855-1860
[10]   TAKAYASU ARTERITIS [J].
KERR, GS ;
HALLAHAN, CW ;
GIORDANO, J ;
LEAVITT, RY ;
FAUCI, AS ;
ROTTEM, M ;
HOFFMAN, GS .
ANNALS OF INTERNAL MEDICINE, 1994, 120 (11) :919-929