Latest updates on SARS-CoV-2 genomic characterization, drug, and vaccine development; a comprehensive bioinformatics review

被引：5
|
作者：
Sakr, Masarra M. [1 ]
Elsayed, Noha S. [1 ]
El-Housseiny, Ghadir S. [1 ]
机构：
[1] Ain Shams Univ, Fac Pharm, Dept Microbiol & Immunol, Org African Unity St, Cairo 11566, Egypt
来源：
MICROBIAL PATHOGENESIS | 2021年 / 154卷
关键词：
SARS-CoV-2; COVID-19; Genome; Vaccine; Bioinformatics; ACUTE-RESPIRATORY-SYNDROME; SYNDROME-CORONAVIRUS; SPIKE PROTEIN; RNA-SYNTHESIS; VIRUS; ACE2; ENVELOPE; ENTRY; IDENTIFICATION; REPLICATION;
D O I：
10.1016/j.micpath.2021.104809
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Amid the COVID-19 outbreak, several bioinformatic analyses have been conducted on SARS-CoV-2 virus genome. Numerous studies rushed to fill the gap about this novel virus. Comparison with other related sequences, structural predictions of the produced proteins, determination of variations in amino acid residues and depiction of possible drug and vaccine targets have been the focus of scientific research from the beginning of this year. In addition to discussing the viral taxonomy, clinical features, life cycle, and genome organization, this review will focus on the recent updates in genome and viral proteins characterization and potential therapeutic and vaccine candidates developed so far. Comparative studies with related genomes and proteins provide understanding for the viral molecular mechanisms and suggest targets for therapeutics and vaccinology trials to stop the escalation of this new virus. This pandemic, with its resulting social and economic afflictions, will definitely have significant marks on our lives in the following years.
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页数：16
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