The significant effects of cerebral microbleeds on cognitive dysfunction: An updated metaanalysis

被引：36

作者：

Li, Xuanting ^{[1
]}

Yuan, Junliang ^{[1
]}

Yang, Lei ^{[1
]}

Qin, Wei ^{[1
]}

Yang, Shuna ^{[1
]}

Li, Yue ^{[1
]}

Fan, Huimin ^{[1
]}

Hu, Wenli ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Beijing, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 09期

基金：

中国国家自然科学基金;

关键词：

SMALL-VESSEL DISEASE; ALZHEIMER-DISEASE; CEREBROVASCULAR-DISEASE; NEUROLOGICAL DISORDER; BRAIN MICROBLEEDS; BLOOD-FLOW; ASSOCIATION; DEMENTIA; DECLINE; MEMORY;

D O I：

10.1371/journal.pone.0185145

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective Accumulated data suggests that cerebral microbleeds (CMBs) play an important role in the decline of cognitive function, but the results remain inconsistent. In the current study, we aimed to investigate the association between CMBs and cognitive function, as well as the various effects of CMBs on different domains of cognition. Methods We searched through the databases of PubMed, Embase, Cochrane Library, and ScienceDirect. After a consistency test, the publication bias was evaluated and a sensitivity analysis was performed with combined odds ratios (OR) and standardized mean difference (SMD) of CMBs. Results A meta-analysis of 25 studies with 9343 participants total was conducted. Patients with CMBs had higher incidence of cognitive impairment (OR: 3.5410; 95% confidence interval [CI] [2.2979, 5.4567], p< 0.05) and lower scores of cognitive functions (SMD: -0.2700 [-0.4267, -0.1133], p< 0.05 in Mini-Mental State Examination [MMSE] group and -0.4869 [-0.8902, -0.0818], p< 0.05 in Montreal Cognitive Assessment [MoCA] group). Our results also indicated that patients with CMBs had obvious decline in cognitive functions, for instance, orientation (SMD: -0.9565 [-1.7260, -0.1869], p< 0.05), attention and calculation (SMD: -1.1518 [-1.9553, -0.3484], p< 0.05) and delayed recall (SMD: -0.5527 [-1.1043, -0.0011], p = 0.05). Conclusions Our data suggested that CMBs might be an important risk factor for cognitive dysfunction, especially in the domains of orientation, attention and calculation and delayed recall functions. Prospective cohort studies with further investigations will be needed in larger samples.

引用

页数：13

共 40 条

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