Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy

被引：12

作者：

Wang, Shusheng

Liu, Dan

Zhang, Xu

Li, Shengyu

Sun, Yongxu

Li, Jia

Zhou, Yifa ^{[1
]}

Zhang, Liping

机构：

[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China

[2] Anhui Univ, Sch Life Sci, Hefei 230039, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 09期

关键词：

toxoflavins; toxoflavin glycosides; prodrugs; beta-glucosidase; anticancer;

D O I：

10.1016/j.carres.2007.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by C-13 NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against P-glucosidase (EC.3.2.1.21). (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1254 / 1260

页数：7

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