Copper(I) Oxide/N,N-Bis[(2-furyl)methyl]oxalamide-Catalyzed Coupling of (Hetero)aryl Halides and Nitrogen Heterocycles at Low Catalytic Loading

被引：56
作者：
Pawar, Govind Goroba [1 ]
Wu, Haibo [1 ]
De, Subhadip [1 ]
Ma, Dawei [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 354 Fenglin Lu, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 10期
基金：
中国国家自然科学基金;
关键词：
aryl halides; copper salts; coupling; low catalytic loading; nitrogen heterocycles; BOND-FORMING REACTIONS; N-ARYLATION; C-N; ARYL HALIDES; EFFICIENT LIGAND; HETEROARYL HALIDES; HIGHLY EFFICIENT; MILD CONDITIONS; EXCELLENT LIGAND; CROSS-COUPLINGS;
D O I：
10.1002/adsc.201700026
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An easily prepared oxalic diamide is a powerful ligand for the copper-catalyzed coupling of aryl halides with nitrogen heterocycles. Only 1-2mol% each of copper(I) oxide and N,N-bis[(2-furyl)methyl]oxalamide (BFMO) are needed to form N-arylation products under mild conditions. More than 10 different types of nitrogen heterocycles are compatible with these conditions, thereby giving the corresponding N-arylation products.
引用
收藏
页码：1631 / 1636
页数：6
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