Adverse Effects of Proton Pump Inhibitors-Evidence and Plausibility

被引：119

作者：

Fossmark, Reidar ^{[1
,2
]}

Martinsen, Tom C. ^{[1
,2
]}

Waldum, Helge L. ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol NTNU, Dept Clin & Mol Med, Fac Med & Hlth Sci, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway

[2] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Gastroenterol & Hepatol, Prinsesse Kristinas Gate 1, N-7030 Trondheim, Norway

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 20期

关键词：

proton pump inhibitors; adverse effects; gastrin; gastric cancer; renal disease; liver disease; fracture risk; LONG-TERM USE; SPONTANEOUS BACTERIAL PERITONITIS; ACUTE INTERSTITIAL NEPHRITIS; RECEPTOR ANTAGONIST USE; BONE-MINERAL DENSITY; FUNDIC GLAND POLYPS; HEPATIC-ENCEPHALOPATHY; PERNICIOUS-ANEMIA; CELL CARCINOIDS; GASTRIC-CANCER;

D O I：

10.3390/ijms20205203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential side effects are causal. However, important evidence from experimental and mechanistic studies that could support a causal relationship may have been underestimated by epidemiologists and meta-analysists. In the current manuscript we review the combined epidemiological and mechanistic evidence of the adverse effects of PPI use.

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页数：15

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