LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway

被引：138

作者：

Zhan, Han-xiang ^{[1
]}

Wang, Yao ^{[2
,3
]}

Li, Ce ^{[2
,3
]}

Xu, Jian-wei ^{[1
]}

Zhou, Bin ^{[4
]}

Zhu, Jian-kang ^{[1
]}

Han, Hai-feng ^{[1
]}

Wang, Lei ^{[1
]}

Wang, Yun-shan ^{[2
]}

Hu, San-yuan ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Sch Ocean, Int Biotechnol R&D Ctr, Weihai 264209, Shandong, Peoples R China

[3] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

[4] Qingdao Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Qingdao 266003, Shandong, Peoples R China

来源：

CANCER LETTERS | 2016年 / 374卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Pancreatic cancer; LincRNA-ROR; Epithelial-mesenchymal transition; ZEB1; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; LONG NONCODING RNAS; POOR-PROGNOSIS; STEM-CELLS;

D O I：

10.1016/j.canlet.2016.02.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer (PC) remains one of the most lethal malignant tumors; early distant metastasis commonly results in poor prognosis. Recent studies confirmed the pivotal role of the long non-coding RNAs (lncRNAs) in tumorigenesis and metastasis of malignant tumors, including PC. However, little is known about the role of LincRNA-ROR (linc-ROR) in PC. In the present study, we found that linc-ROR was upregulated in PC tissues. Overexpression of linc-ROR promoted cells proliferation, migration, invasion and metastasis both in vitro and in a mouse model. Contrarily, knockdown of linc-ROR attenuated proliferation, invasion and distant metastasis. Mechanistically, we confirmed that linc-ROR up-regulates ZEB1 and then induces epithelial-mesenchymal transition (EMT), which promotes the aggressive biological behaviors of PC. Together, these results indicate that linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in PC, and may represent a novel therapeutic target. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：261 / 271

页数：11

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