Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Allylation of Pyridazinones with Terminal Allenes

被引：28

作者：

Parveen, Shaista ^{[1
,2
]}

Li, Changkun ^{[1
]}

Hassan, Abbas ^{[1
,2
]}

Breit, Bernhard ^{[1
]}

机构：

[1] Albert Ludwigs Univ Freiburg, Inst Organ Chem, Albertstr 21, D-79104 Freiburg, Germany

[2] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 09期

关键词：

MET KINASE INHIBITORS; HOMOGENEOUS CATALYSIS; BIOLOGICAL EVALUATION; ALLYLIC ALKYLATIONS; DERIVATIVES; AMINATION; DISCOVERY; ALKENES; DIASTEREOSELECTIVITY; HYDROFORMYLATION;

D O I：

10.1021/acs.orglett.7b00718

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium-catalyzed addition of pyridazinones to terminal allenes furnished the corresponding, branched N-2-allylated products in good yields with high regio- and enantioselectivities. A broad functional group compatibility was observed, and assorted synthetic transformations of the N-allylpyridazinones led to the preparation of a small library of N-2-functionalized pyridazinones. Labeling experiments with deuterated substrates provided insights into the underlying reaction mechanism.

引用

页码：2326 / 2329

页数：4

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