Fe/Mn Multilayer Nanowires as High-Performance T1-T2 Dual Modal MRI Contrast Agents

被引：12

作者：

Cao, Xiaoming ^{[1
]}

Gu, Liyuan ^{[2
]}

Hu, Shike ^{[2
]}

Mukhtar, Aiman ^{[1
]}

Wu, Kaiming ^{[1
]}

机构：

[1] Wuhan Univ Sci & Technol, State Key Lab Refractories & Met, Hubei Prov Key Lab Syst Sci Met Proc, Collaborat Innovat Ctr Adv Steels,Int Res Inst St, Wuhan 430081, Peoples R China

[2] Hubei Univ Sci & Technol, Res & Dev Ctr Nonpowered Nucl Technol, Xianning 437000, Peoples R China

来源：

MATERIALS | 2021年 / 14卷 / 09期

关键词：

dual modal; MRI; CAs; nanowire; relaxation; IRON-OXIDE NANOPARTICLES; T-1; RELAXIVITY; DESIGN;

D O I：

10.3390/ma14092238

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A lot of nanomaterials are using T-1-T-2 dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T-1-T-2 dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T-1-T-2 dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r(1) value (21.8 mM(-1)s(-1)) and r(2) value (74.8 mM(-1)s(-1)) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM(-1)s(-1)) and Fe NW (59.3 mM(-1)s(-1)), respectively. We predict that our Fe/Mn multilayer NW could be used as T-1-T-2 dual mode MRI CAs in the near future.

引用

页数：15

共 38 条

[1] Synthesis of Uniformly Sized Manganese Oxide Nanocrystals with Various Sizes and Shapes and Characterization of Their T1 Magnetic Resonance Relaxivity [J].