Fe/Mn Multilayer Nanowires as High-Performance T1-T2 Dual Modal MRI Contrast Agents

被引：11
作者：
Cao, Xiaoming [1 ]
Gu, Liyuan [2 ]
Hu, Shike [2 ]
Mukhtar, Aiman [1 ]
Wu, Kaiming [1 ]
机构：
[1] Wuhan Univ Sci & Technol, State Key Lab Refractories & Met, Hubei Prov Key Lab Syst Sci Met Proc, Collaborat Innovat Ctr Adv Steels,Int Res Inst St, Wuhan 430081, Peoples R China
[2] Hubei Univ Sci & Technol, Res & Dev Ctr Nonpowered Nucl Technol, Xianning 437000, Peoples R China
来源：
MATERIALS | 2021年 / 14卷 / 09期
关键词：
dual modal; MRI; CAs; nanowire; relaxation; IRON-OXIDE NANOPARTICLES; T-1; RELAXIVITY; DESIGN;
D O I：
10.3390/ma14092238
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A lot of nanomaterials are using T-1-T-2 dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T-1-T-2 dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T-1-T-2 dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r(1) value (21.8 mM(-1)s(-1)) and r(2) value (74.8 mM(-1)s(-1)) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM(-1)s(-1)) and Fe NW (59.3 mM(-1)s(-1)), respectively. We predict that our Fe/Mn multilayer NW could be used as T-1-T-2 dual mode MRI CAs in the near future.
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页数：15
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