An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination

被引：5

作者：

Yoshimura, Yukihiro ^{[1
]}

Sasaki, Hiroaki ^{[1
]}

Miyata, Nobuyuki ^{[1
]}

Miyazaki, Kazuhito ^{[2
]}

Okudela, Koji ^{[3
]}

Tateishi, Yoko ^{[4
]}

Hayashi, Hiroyuki ^{[4
]}

Kawana-Tachikawa, Ai ^{[5
]}

Iwashita, Hiromichi ^{[3
]}

Maeda, Kazuho ^{[6
]}

Ihama, Yoko ^{[6
]}

Hatayama, Yasuyoshi ^{[7
]}

Ryo, Akihide ^{[7
]}

Tachikawa, Natsuo ^{[1
]}

机构：

[1] Yokohama Municipal Citizens Hosp, Dept Infect Dis, Yokohama, Kanagawa, Japan

[2] Yokohama Municipal Citizens Hosp, Dept Resp Med, Yokohama, Kanagawa, Japan

[3] Yokohama City Univ, Dept Pathol, Grad Sch Med, Yokohama, Kanagawa, Japan

[4] Yokohama Municipal Citizens Hosp, Dept Pathol, Yokohama, Kanagawa, Japan

[5] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan

[6] Yokohama City Univ, Dept Legal Med, Grad Sch Med, Yokohama, Kanagawa, Japan

[7] Yokohama City Univ, Dept Microbiol, Sch Med, Yokohama, Kanagawa, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 121卷

关键词：

COVID-19; vaccine; acute respiratory distress syndrome; autopsy;

D O I：

10.1016/j.ijid.2022.04.057

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the first case with COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination. An 88-year-old woman developed dyspnea several hours after vaccination with the second dose of mRNA-1273. She was hospitalized on day nine due to worsening dyspnea. Chest computed tomography showed bilateral ground-glass opacities and consolidations, mainly in the peripheral lung areas. Repeat polymerase chain reaction tests for SARS-CoV-2 were negative, although the serum level of antibodies against spike protein was extremely elevated. Her condition did not improve with high-dose corticosteroids and high-flow nasal cannula oxygen therapy; she died on day 18. Autopsy findings revealed very early-phase diffuse alveolar damage in the whole lung without other lung diseases. The clinical and pathological findings suggested vaccine-induced acute respiratory distress syndrome. Serological and pathological tests might be useful to differentiate the disease from COVID-19. (C) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：98 / 101

页数：4

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