Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease

被引：34
作者：
Bialecka, M.
Klodowska-Duda, G.
Honczarenko, K.
Gawronska-Szklarz, B.
Opala, G.
Safranow, K.
Drozdzik, M.
机构：
[1] Pomeranian Med Univ, Dept Expt & Clin Pharmacol, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Neurol, PL-70111 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, PL-70111 Szczecin, Poland
[4] Pomeranian Med Univ, Dept Biochem, PL-70111 Szczecin, Poland
[5] Med Univ Silesia, Dept Neurol Ageing & Degenerat & Cerebrovasc Dis, Katowice, Poland
来源：
PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 04期
关键词：
Parkinson's disease; COMT; MAOB; NAT2; CYP2D6; polymorphism;
D O I：
10.1016/j.parkreldis.2006.10.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of the present study was to evaluate the contribution of MAOB, COMT, NAT2 and CYP2D6 gene polymorphisms to early onset Parkinson's disease (PD). The study enrolled 134 patients with Parkinson's disease (early onset-EOPD-67 patients, and late onset-LOPD-patients), and 66 healthy individuals. Polymerane chain reaction restriction fragment length polymorphism (PCR-RFLP) methods were used for genotyping. Univariate analysis revealed a significant two-fold higher EOPD risk among carriers of MAOB allele A or AA genotype. Multivariate analysis revealed that MAOB allele A was an independent factor predisposing to EOPD. It was shown that neither NAT2, CYP2D6 nor COMT genotype was associated with PD. (C) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：224 / 229
页数：6
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