Genes and parkinsonism

被引：83
作者：
Hardy, J [1 ]
Cookson, MR [1 ]
Singleton, A [1 ]
机构：
[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA
来源：
LANCET NEUROLOGY | 2003年 / 2卷 / 04期
关键词：
D O I：
10.1016/S1474-4422(03)00350-8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Genetic studies in families with mendelian inheritance of Parkinson's disease (PD) have reported the cloning of several disease-associated genes. These studies of rare familial forms of the disease have cast doubt on our understanding of the role of genetics in typical PD and have complicated the classification of the disorder. However, this genetic information might help us to construct a hypothesis for the pathogenetic processes that underlie PD. In this review we describe the molecular genetics of PD as currently understood to help explain the pathways that underlie neurodegeneration.
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页码：221 / 228
页数：8
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