Cobalt-Catalyzed C(sp2)-H Alkoxylation of Aromatic and Olefinic Carboxamides

被引：201

作者：

Zhang, Lin-Bao ^{[1
]}

Hao, Xin-Qi ^{[1
]}

Zhang, Shou-Kun ^{[1
]}

Liu, Zhan-Jiang ^{[1
]}

Zheng, Xin-Xiang ^{[1
]}

Gong, Jun-Fang ^{[1
]}

Niu, Jun-Long ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Henan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 01期

基金：

中国国家自然科学基金;

关键词：

alkoxylation; C-H activation; cobalt; directing groups; transition-metal catalysis; C-H BONDS; BIDENTATE-CHELATION ASSISTANCE; UNACTIVATED C(SP(3))-H BONDS; DIRECTING GROUP; COUPLING REACTIONS; ACID-DERIVATIVES; PRIMARY ALCOHOLS; DIRECT ARYLATION; ARYL ETHERS; FUNCTIONALIZATION;

D O I：

10.1002/anie.201409751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cobalt-catalyzed alkoxylation of C(sp(2))H bonds in aromatic and olefinic carboxamides has been developed. The reaction proceeded under mild conditions in the presence of Co(OAc)(2)4H(2)O as the catalyst and tolerates a wide range of both alcohols and benzamide substrates, including even olefinic carboxamides. In addition, this reaction is the first example of the direct alkoxylation of alkenes through CH bond activation.

引用

页码：272 / 275

页数：4

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