Management of venous thromboembolism in patients with acute leukemia at high bleeding risk: a multi-center study

被引：16

作者：

Napolitano, Mariasanta ^{[1
,2
]}

Valore, Luca ^{[1
,2
]}

Malato, Alessandra ^{[3
]}

Saccullo, Giorgia ^{[1
,2
]}

Vetro, Calogero ^{[4
]}

Mitra, Maria Enza ^{[1
,2
]}

Fabbiano, Francesco ^{[3
]}

Mannina, Donato ^{[5
]}

Casuccio, Alessandra ^{[6
]}

Lucchesi, Alessandro ^{[7
]}

Del Principe, Maria Ilaria ^{[8
]}

Candoni, Anna ^{[9
]}

Di Raimondo, Francesco ^{[4
]}

Siragusa, Sergio ^{[1
,2
]}

机构：

[1] Univ Palermo, Hematol Unit, Palermo, Italy

[2] Univ Palermo, Thrombosis & Hemostasis Reference Reg Ctr, Palermo, Italy

[3] Gen Hosp Cervello, Hematol Unit, Palermo, Italy

[4] Univ Hosp Catania, Dept Clin & Mol BioMed, Hematol Unit, Catania, Italy

[5] Papardo Gen Hosp, Hematol Unit, Messina, Italy

[6] Univ Palermo, Dept Hlth Promot Sci & Mother Child Care, Palermo, Italy

[7] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori, Hematol & Oncol Unit, Meldola, Italy

[8] Tor Vergata Univ Hosp, Hematol Unit, Rome, Italy

[9] Udine Univ Hosp, Hematol Unit, Udine, Italy

来源：

LEUKEMIA & LYMPHOMA | 2016年 / 57卷 / 01期

关键词：

Venous thrombosis; acute leukemia; low molecular weight heparin; SINGLE-CENTER EXPERIENCE; CANCER-PATIENTS; THROMBOSIS; SURVIVAL; ENOXAPARIN; DIAGNOSIS; PROGNOSIS;

D O I：

10.3109/10428194.2015.1046864

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. The authors performed a multi-center study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. The intention was to find as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.

引用

页码：116 / 119

页数：4

共 25 条

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