Catechin-Modified Polylactide Stereocomplex at Chain End Improved Antibiobacterial Property

被引：19

作者：

Ajiro, Hiroharu ^{[1
,2
,3
,4
,5
]}

Ito, Shogo ^{[4
]}

Kan, Kai ^{[2
]}

Akashi, Mitsuru ^{[4
,5
,6
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, 8916-5 Takayama, Nara 6300192, Japan

[2] Nara Inst Sci & Technol, Inst Res Initiat, Div Res Strategy, 8916-5 Takayama, Nara 6300192, Japan

[3] JST PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

[4] Osaka Univ, Dept Appl Chem, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

[5] Osaka Univ, Ctr Adv Med Engn & Informat, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[6] Osaka Univ, Grad Sch Frontier Biosci, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

MACROMOLECULAR BIOSCIENCE | 2016年 / 16卷 / 05期

关键词：

antibacterial; biomaterials; polylactide; stereocomplex; thin films; SILVER NANOPARTICLES; BACTERICIDAL ACTION; ETHYLENE-OXIDE; STERILIZATION; POLYMERS; PLA; POLY(LACTIDE)S; MICROSPHERES; POLYESTERS; COPOLYMERS;

D O I：

10.1002/mabi.201500398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using different type of initiators, the antibacterial moieties are introduced at the chain end of poly(L,L-lactide) (PLLA) and poly(D,D-lactide) (PDLA), and the thermal properties are simultaneously improved using the stereocomplex approach. The physical interaction of polymers and antibacterial compounds is investigated. The double bonds at the chain end are utilized for the interaction of silver ion; however, the silver ions are not detected after stereocomplexation of PLLA and PDLA. On the other hand, catechin (CT) is selected as an initiator precursor of lactide polymerization, protecting the phenolic hydroxyl groups. The linear PLLA and PDLA are obtained by the initiator, resulting in CT conjugated PLAs at the chain end groups after deprotection of phenolic hydroxyl groups. The antibacterial properties are determined by proliferation tests of staphylococcus aureus. The results suggest that the antibacterial properties of CT modified PLAs are derived from the original CT parts.

引用

页码：694 / 704

页数：11

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