Anti-tumor and Antimicrobial Activities of β-Carbolines

被引：2

作者：

Liu Li ^{[1
]}

Ma Yangyang ^{[2
]}

Wang Kuan ^{[1
]}

Jia Yunjing ^{[2
]}

Li Wan ^{[2
]}

Zhu Huajie ^{[2
]}

机构：

[1] Hebei Univ, Coll Med, Baoding 071000, Peoples R China

[2] Hebei Univ, Coll Pharmaceut Sci, Baoding 071000, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2018年 / 39卷 / 04期

关键词：

beta-Carboline; Antimicrobial activity; Anti-tumor activity; Chiral compound; ANTICANCER AGENTS; DERIVATIVES; DESIGN; INHIBITORS; BISCARBOLINE; BINDING; ACIDS;

D O I：

10.7503/cjcu20170636

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of beta-carbolines possessing different substituents at C1, C3 and N9 positions derived from L-tryptophan was used in anti-tumour and antimicrobial activity study. Compound 3b exhibited anti-tumour activity against tumour cell line A459 with a IC50 value of 3.17 mu mol/L in vitro by methyl thiazolyl tetrazolium(MTT) assay while the positive control group(cis-platin, DDP) was 1.45 mu mol/L. Other eleven compounds showed relatively weak activities against the five cell-lines. Compound 5h exhibited activitiy against vibrio anguillarum with a MIC value of 0.78 mu mol/L while the positive control group(ciprofloxacin) was 1.25 mu mol/L. Other fourteen compounds showed relatively weak activities against five spices of bacteria. By the study of structural-activity relationship, optimizing structures is possible and necessary in the future to screen potential compounds for medicinal study.

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收藏

页码：674 / 680

页数：7

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