Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma

被引：18

作者：

Primerano, Simona ^{[1
]}

Burnelli, Roberta ^{[2
]}

Carraro, Elisa ^{[1
]}

Pillon, Marta ^{[1
]}

Elia, Caterina ^{[3
]}

Farruggia, Piero ^{[4
]}

Sala, Alessandra ^{[5
]}

Vinti, Luciana ^{[6
]}

Buffardi, Salvatore ^{[7
]}

Basso, Giuseppe ^{[1
]}

Mascarin, Maurizio ^{[3
]}

Mussolin, Lara ^{[1
,8
]}

机构：

[1] Azienda Osped Univ Padova, Dipartimento Salute Donna & Bambino, Clin Oncoematol Pediat, Padua, Italy

[2] Azienda Osped Univ Ferrara S Anna, Unita Oncoematol, Ferrara, Italy

[3] SOS Radioterapia Pediat CRO Aviano, Rome, Italy

[4] ARNAS Osped Civ Cristina & Benfratelli, Unita Oncoematol Pediat, Dipartimento Oncol, Palermo, Italy

[5] Univ Milano Bicocca, Osped S Gerardo, Fdn Monza & Brianza Bambino & Sua Mamma, Pediat Clin, Monza, Italy

[6] Bambino Gesu Pediat Hosp, Dipartimento Oncoematol Pediat, Rome, Italy

[7] Osped Santobono Pausillipon, Dipartimento Oncol Pediat, Naples, Italy

[8] Fdn Citta Speranza, Ist Ric Pediat, Padua, Italy

来源：

JOURNAL OF CANCER | 2016年 / 7卷 / 04期

关键词：

classical Hodgkin Lymphoma; cell-free DNA; childhood; RELEASE; TUMORS;

D O I：

10.7150/jca.13593

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA at diagnosis was correlated with presence of B symptoms (p=0.027) and high erythrocyte sedimentation rate (p=0.049). We found that the increasing of plasma cfDNA after first chemotherapy cycle seems to be associated with a worse prognosis (p=0.049). Levels of plasma cfDNA might constitute an interesting non-invasive tool in cHL patients' management.

引用

页码：364 / 366

页数：3

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