Neurobiology of butyrylcholinesterase

被引：728

作者：

Darvesh, S ^{[1
]}

Hopkins, DA

Geula, C

机构：

[1] Dalhousie Univ, Dept Med, Halifax, NS, Canada

[2] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada

[3] Harvard Univ, Sch Med, Dept Med, Lab Neurodegenerat & Aging Res, Boston, MA 02215 USA

[4] Beth Israel Deaconess Med Ctr, Sect Gerontol, Boston, MA 02215 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2003年 / 4卷 / 02期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nrn1035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function. Here, we summarize the biochemical properties of butyrylcholinesterase and review the evidence that this enzyme has important roles in cholinergic neurotransmission and could be involved in other nervous system functions and in neurodegenerative diseases.

引用

页码：131 / 138

页数：8

共 127 条

[1] THE CLONED BUTYRYLCHOLINESTERASE (BCHE) GENE MAPS TO A SINGLE CHROMOSOME SITE, 3Q26 [J].