In-Process Temperature Mapping System for Industrial Freeze Dryers

被引:20
作者
Corbellini, Simone [1 ]
Parvis, Marco [1 ]
Vallan, Alberto [1 ]
机构
[1] Politecn Torino, Dipartimento Elettron, I-10129 Turin, Italy
关键词
Freeze drying; low invasive; temperature measurement; vial; wireless; PRODUCT TEMPERATURE;
D O I
10.1109/TIM.2010.2040909
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper describes a low-invasive temperature mapping system specially designed for vacuum and nonaccessible environments, such as industrial freeze dryers. Thermal resistances tend to become quite hight in vacuum since convection is absent and even very small gaps have extremely conductive resistances. Temperature monitoring in the vacuum therefore requires sensors that do not inject power to minimize the self-heating and a special attention to the effect due to the involved thermal resistances. The proposed solution employs small autonomous measuring nodes that use a wireless connection to transmit the results and that are characterized to correct the thermal constant effect during temperature changes. The system has been designed for the monitoring of large freeze dryers, but its characteristics make it useful in many other vacuum conditions. The system is capable of monitoring the temperature of hundreds of points with an uncertainty of the order of a degree and with a cost per point of a few euros.
引用
收藏
页码:1134 / 1140
页数:7
相关论文
共 15 条
[1]   In-line control of the lyophilization process. A gentle PAT approach using software sensors [J].
Barresi, Antonello A. ;
Velardi, Salvatore A. ;
Pisano, Roberto ;
Rasetto, Valeria ;
Vallan, Alberto ;
Galan, Miquel .
INTERNATIONAL JOURNAL OF REFRIGERATION-REVUE INTERNATIONALE DU FROID, 2009, 32 (05) :1003-1014
[2]   Heat transfer in vial lyophilization [J].
Brülls, M ;
Rasmuson, A .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 246 (1-2) :1-16
[3]   A Measuring System for the Assurance of the Cold-Chain Integrity [J].
Carullo, A. ;
Corbellini, S. ;
Parvis, M. ;
Reyneri, L. ;
Vallan, A. .
2008 IEEE INSTRUMENTATION AND MEASUREMENT TECHNOLOGY CONFERENCE, VOLS 1-5, 2008, :1598-1602
[4]   Optimization of the freeze-drying cycle: A new model for pressure rise analysis [J].
Chouvenc, P ;
Vessot, S ;
Andrieu, J ;
Vacus, P .
DRYING TECHNOLOGY, 2004, 22 (07) :1577-1601
[5]  
CORBELLINI S, 2005, P IEEE INSTR MEAS TE, V1, P565
[6]  
Corbellini S, 2009, IEEE IMTC P, P76
[7]   A System for Monitoring Workers' Safety in an Unhealthy Environment by means of Wearable Sensors [J].
Corbellini, Simone ;
Ferraris, Franco ;
Parvis, Marco .
2008 IEEE INSTRUMENTATION AND MEASUREMENT TECHNOLOGY CONFERENCE, VOLS 1-5, 2008, :951-955
[8]  
Oetjen G.W., 1999, FREEZE DRYING
[9]  
PIKAL MJ, 2002, FREEZE DRYING ENCY P
[10]  
*RFID, RFID RAD FREQ ID TEC