Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later

被引：62

作者：

Huang, Shao Hui ^{[1
]}

Waldron, John ^{[1
,2
]}

Bratman, Scott V. ^{[1
]}

Su, Jie ^{[3
]}

Kim, John ^{[1
]}

Bayley, Andrew ^{[1
]}

Cho, John ^{[1
]}

Giuliani, Meredith ^{[1
]}

Hope, Andrew ^{[1
]}

Ringash, Jolie ^{[1
]}

Hansen, Aaron ^{[4
]}

de Almeida, John R. ^{[2
]}

Goldstein, David ^{[2
]}

Perez-Ordonez, Bayardo ^{[5
]}

Weinreb, Ilan ^{[5
]}

Tong, Li ^{[1
]}

Xu, Wei ^{[3
]}

O'Sullivan, Brian ^{[1
,2
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol, Toronto, ON, Canada

[5] Univ Toronto, Princess Margaret Canc Ctr, Dept Pathol, Toronto, ON, Canada

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2017年 / 98卷 / 01期

关键词：

SQUAMOUS-CELL CARCINOMA; OROPHARYNGEAL CANCER; CONTRALATERAL NECK; REGIONAL FAILURE; RADIOTHERAPY; IRRADIATION; METASTASES; PATTERNS; THERAPY; FREEDOM;

D O I：

10.1016/j.ijrobp.2017.01.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To report the outcome of ipsilateral radiation therapy (RT) in human papillomavirus (HPV)-positive (HPV+) patients and HPV-negative (HPV -) patients with T1-T2N0-N2b tonsillar cancer treated 25 years after our initial historical cohort. Methods and Materials: Patients with T1-T2N0-N2b tonsillar cancer who received ipsilateral RT or bilateral RT between 1999 and 2014 were reviewed. Overall survival (OS), local control (LC), regional control (RC), and grade 3 to 4 late toxicity (LT) were compared between ipsilateral RT and bilateral RT within HPV+ and HPV- patients, separately. Results: HPV status was ascertained in 379/427 (88%) consecutive patients (ipsilateral RT: 62 HPV+, 34 HPV-; bilateral RT: 240 HPV+ 240, 41 HPV-). The proportion of ipsilateral RT by N category for HPV+ and HPV- patients were as follows: N0: 24/37 (65%) versus 28/48 (74%); N1: 21/49 (43%) versus 4/9 (44%); N2a:10/39 (26%) versus 1/4 (25%); and N2b: 7/177 (4%) versus 1/24 (4%), respectively. Of the patients receiving ipsilateral RT, 94/96 (98%) were treated with RT alone. The median follow-up time was 5.03 years. The respective 5-year rates of OS, LC, RC, and LT were similar between ipsilateral RT and bilateral RT for the HPV+ patients (OS: 89% vs 87%, PZ=. 55; LC: 97% vs 98%, PZ=. 65; RC: 98% vs 97%, PZ=. 27; LT: 17% vs 12%, PZ=. 83) and HPV- patients (OS: 63% vs 48%, PZ.= 27; LC: 90% vs 80%, PZ=. 19; RC: 94% vs 83%, PZ=. 14; LT: 15% vs 22%, PZ=. 36). Of the 96 patients receiving ipsilateral RT, contralateral neck failure (CNF) occurred in 1/52 HPV+ patients and 1/34 HPV- patients. The 5- year CNF rates were 2% (95% CI: 1- 9) (HPV+: 2% [0-14]; HPV- : 3% [0-21], PZ=. 66). Five local failures (2 HPV+; 3 HPV-) and no distant failures were seen. The 5- year rates of LC, RC, and LT were 97% versus 90% (PZ=. 24), 98% versus 94% (PZ=. 25), and 18% versus 15% (PZ. 75) for the HPV_ and HPV- cohorts, respectively. Osteoradionecrosis occurred in 9 patients: 6/47 (13%) treated with conventional RT and 3/49 (6%) with intensity modulated RT (PZ = .32). Conclusion: Ipsilateral radiation to selected patients with T1-T2N0-N2b tonsillar cancer results in equally excellent outcomes regardless of tumor HPV status. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：159 / 169

页数：11

共 32 条

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