DNAzyme sensors for detection of metal ions in the environment and imaging them in living cells

被引:115
作者
McGhee, Claire E. [1 ]
Loh, Kang Yong [1 ]
Lu, Yi [1 ]
机构
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
基金
美国国家卫生研究院;
关键词
IN-VITRO SELECTION; LANTHANIDE-DEPENDENT DNAZYME; BIOSTABLE L-DNAZYME; LABEL-FREE; ELECTROCHEMICAL BIOSENSOR; COLORIMETRIC DETECTION; SENSITIVE DETECTION; SENSING STRATEGY; GENERAL-METHOD; RNA CLEAVAGE;
D O I
10.1016/j.copbio.2017.03.002
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The on-site and real-time detection of metal ions is important for environmental monitoring and for understanding the impact of metal ions on human health. However, developing sensors selective for a wide range of metal ions that can work in the complex matrices of untreated samples and cells presents significant challenges. To meet these challenges, DNAzymes, an emerging class of metal ion-dependent enzymes selective for almost any metal ion, have been functionalized with fluorophores, nanoparticles and other imaging agents and incorporated into sensors for the detection of metal ions in environmental samples and for imaging metal ions in living cells. Herein, we highlight the recent developments of DNAzyme-based fluorescent, colorimetric, SERS, electrochemical and electrochemiluminscent sensors for metal ions for these applications.
引用
收藏
页码:191 / 201
页数:11
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