Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis

被引：127
作者：
Prayle, Andrew [1 ]
Watson, Alan [2 ]
Fortnum, Heather [3 ]
Smyth, Alan [1 ]
机构：
[1] Univ Nottingham, Child Hlth & Nottingham Resp Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
[2] Univ Nottingham Hosp, Childrens Renal & Urol Unit, Nottingham NG7 2UH, England
[3] Univ Nottingham, Natl Biomed Res Unit Hearing, Nottingham, England
来源：
THORAX | 2010年 / 65卷 / 07期
基金：
美国国家卫生研究院;
关键词：
ACUTE-RENAL-FAILURE; MITOCHONDRIAL 1555A-GREATER-THAN-G MUTATION; GENTAMICIN-INDUCED OTOTOXICITY; INDUCED HEARING-LOSS; TOBRAMYCIN TREATMENT; D-GLUCOSAMINIDASE; RISK-FACTORS; HAIR-CELLS; PHARMACOKINETICS; NEPHROTOXICITY;
D O I：
10.1136/thx.2009.131532
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Aminoglycoside antibiotics are a central component of the treatment of pulmonary exacerbations of cystic fibrosis (CF) and slow the decline in lung function which ultimately causes the death of most patients. The prognosis of CF has improved, and thus side effects of treatments have become increasingly important. Observational studies suggest that the morbidity from side effects of aminoglycosides is disturbingly common, and that aggressive treatment may lead to more side effects. This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies. Treatments which have shown early promise are identified and areas of future research are discussed.
引用
收藏
页码：654 / 658
页数：5
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