Acute lymphoblastic leukemia in patients with Down syndrome with a previous history of acute myeloid leukemia

被引：2

作者：

Tomizawa, Daisuke ^{[1
,2
]}

Endo, Akifumi ^{[2
]}

Kajiwara, Michiko ^{[2
]}

Sakaguchi, Hirotoshi ^{[3
]}

Matsumoto, Kimikazu ^{[1
,3
]}

Kaneda, Makoto ^{[4
]}

Taga, Takashi ^{[5
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

[2] Tokyo Med & Dent Univ, Dept Pediat, Tokyo, Japan

[3] Japanese Red Cross Nagoya First Hosp, Dept Hematol & Oncol, Childrens Med Ctr, Nagoya, Aichi, Japan

[4] Asahikawa Med Univ, Dept Pediat, Asahikawa, Hokkaido, Japan

[5] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 08期

关键词：

acute lymphoblastic leukemia; acute myeloid leukemia; Down syndrome; CHILDREN; CRLF2;

D O I：

10.1002/pbc.26411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with Down syndrome (DS) are predisposed to acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in early and later childhood, respectively, but rarely experience both. We herein discuss four patients with DS with ALL and a history of AML who were treated with various chemotherapies, one of whom later received a bone marrow transplantation. Three patients survived and remain in remission. One patient died of fulminant hepatitis during therapy. No common cytogenetic abnormalities in AML and ALL besides constitutional +21 were identified, indicating that the two leukemia types were independent events. However, the underlying pathomechanism of these conditions awaits clarification.

引用

页数：4

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