Tubulin as a regulator of G-protein signaling

被引：0

作者：

Rasenick, MM ^{[1
]}

Donati, RJ

Popova, JS

Yu, JZ

机构：

[1] Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

来源：

REGULATORS OF G-PROTEIN SIGNALING, PT B | 2004年 / 390卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tubulin is known to form high-affinity complexes with certain G proteins. The formation of such complexes allows tubulin to activate Galpha and fosters a system whereby elements of the cytoskeleton can influence G-protein signaling. This article describes the interaction between tubulin and G proteins and discusses methods for examining this interaction.

引用

页码：389 / 403

页数：15

共 25 条

[1] EFFECT OF MONOLAYER SURFACE PRESSURE ON THE ACTIVITIES OF PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C-BETA-1, PHOSPHOLIPASE-C-GAMMA-1, AND PHOSPHOLIPASE-C-DELTA-1 [J].

BOGUSLAVSKY, V ;

REBECCHI, M ;

MORRIS, AJ ;

JHON, DY ;

RHEE, SG ;

MCLAUGHLIN, S .

BIOCHEMISTRY, 1994, 33 (10) :3032-3037

[2] A specific domain of Giα required for the transactivation of Giα by tubulin is implicated in the organization of cellular microtubules [J].

Chen, NF ;

Yu, JZ ;

Skiba, NP ;

Hamm, HE ;

Rasenick, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (17) :15285-15290

[3]

FABIATO A, 1988, METHOD ENZYMOL, V157, P378

[4]

GRABER SG, 1992, J BIOL CHEM, V267, P1271

[5]

KENNEDY MS, 1979, MOL PHARMACOL, V16, P215

[6] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[7]

LUTHIN GR, 1984, MOL PHARMACOL, V26, P164

[8]

PARKER EM, 1991, J BIOL CHEM, V266, P519

[9]

POPOVA JS, 1995, J NEUROCHEM, V64, P130

[10] Tubulin, G(q), and phosphatidylinositol 4,5-bisphosphate interact to regulate phospholipase C beta(1) signaling [J].

Popova, JS ;

Garrison, JC ;

Rhee, SG ;

Rasenick, MM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6760-6765

← 1 2 3 →