Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

被引：379

作者：

Citrin, Deborah ^{[1
]}

Cotrim, Ana P. ^{[3
]}

Hyodo, Fuminori ^{[2
]}

Baum, Bruce J. ^{[3
]}

Krishna, Murali C. ^{[2
]}

Mitchell, James B. ^{[2
]}

机构：

[1] NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Radiat Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD USA

来源：

ONCOLOGIST | 2010年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Radioprotector; Mitigators; Amifostine; Tempol; ANGIOTENSIN-CONVERTING ENZYME; KERATINOCYTE GROWTH-FACTOR; SENSITIVE CONTRAST AGENTS; COLONY-STIMULATING FACTOR; TOLL-LIKE RECEPTOR-5; NECK-CANCER PATIENTS; SUPEROXIDE-DISMUTASE; RANDOMIZED-TRIAL; INDUCED FIBROSIS; IRRADIATED MICE;

D O I：

10.1634/theoncologist.2009-S104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compounds are often antioxidants and must be present be-fore or at the time of radiation for effectiveness. Other agents, termed mitigators, may be used to minimize toxicity even after radiation has been delivered. Herein, we review agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury. Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing. The Oncologist 2010; 15: 360-371

引用

页码：360 / 371

页数：12

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